Deoxo-proline-containing tamandarin and didemnin analogs,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S011400, C530S317000, C530S322000, C530S323000, C530S324000, C530S402000

Reexamination Certificate

active

07064105

ABSTRACT:
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

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