Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Patent
1998-04-28
1999-10-19
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
424 68, 424400, 424401, 536 20, A61K 732, A61K 738, A61K 700, C08B 3708
Patent
active
059684887
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to deodorizing formulations containing cationic biopolymers, aluminium chlorohydrate and esterase inhibitors.
Discussion of Related Art
In the field of personal hygiene, deodorants are used to eliminate troublesome body odors. Body odors are formed by the bacterial decomposition of basically odorless perspiration, particularly in the damp underarm regions or under similar conditions favorable to microorganism growth. Body odors can be masked by suitable perfumes. They can also be controlled by using formulations which inhibit the actual secretion of perspiration or its decomposition (so-called antihydrotics, antiperspirants or antitranspirants). Typical examples of such substances are aluminium compounds, such as aluminium sulfate or aluminium chlorohydrate, zinc salts and citric acid compounds. An overview of these agents was published, for example, in Umbach (Ed.), "Kosmetik", pages 141 et seq., Thieme Verlag, Stuttgart, 1988.
However, it is clear from everyday living that the problem of odor inhibition, particularly in heat or in the event of bodily activity, has by no means been completely solved. Commercial products are unable permanently to suppress the secretion of perspiration or the formation of odors. Instead, their inhibiting effect is of limited duration and is also dependent on the extent to which perspiration is secreted. Accordingly, there is a constant need for improved products which minimize the secretion of perspiration and reduce the formation of body odors and which, at the same time, show increased dermatological compatibility, i.e. reduced irritation potential towards particularly sensitive skin. The problem addressed by the present invention was to provide such products.
DESCRIPTION OF THE INVENTION
The present invention relates to deodorizing formulations containing
The use of aluminium chlorohydrates and esterase inhibitors of the triethyl citrate type for producing deodorizing and/or antiperspirant compositions is known from the prior art. It has surprisingly been found that cationic biopolymers, preferably of the chitosan type, inhibit the activity of esterase-producing bacteria and that a synergistic deodorizing effect is obtained in conjunction with the two components mentioned above. The biopolymers have a bacteriostatic effect, i.e. the population of the germs in question is controlled, but not destroyed in order not to impair the biological equilibrium of the dermal flora. At the same time, the use of the cationic biopolymers leads to an improvement in the dermatological compatibility of the products.
Cationic biopolymers
Cationic biopolymers suitable for use as component (a) are preferably partly deacetylated chitins with various molecular weights which contain the--idealized--monomer unit (I): ##STR1## In contrast to most hydrocolloids, which are negatively charged at biological pH values, the chitosans preferably used are cationic compounds under these conditions. The positively charged chitosans are capable of interacting with oppositely charged surfaces and, accordingly, are used in cosmetic hair-care and body-care formulations. Overviews on this subject have been published, for example, by B. Gesslein et al. in HAPPI 27 57 (1990), by O Skaugrud in Drug Cosm. Ind. 148, 24 (1991) and by E. Onsoyen et al. in Seifen-Ole-Fette-Wachse 117 633 (1991). Chitosans are produced from chitin, preferably from the shell remains of crustaceans which are available in large quantities as inexpensive raw materials. Normally, the chitin is first deproteinized by addition of bases, demineralized by addition of mineral acids and, finally, deacetylated by addition of strong bases, the molecular weights being spread over a broad range. Chitosans subsequently degraded with hydrogen peroxide are preferred. Corresponding processes for the production of--microcrystalline--chitosan are described, for example, in WO 91105808 (Firextra Oy) and in EP-B1 0 382 150 (Hoechst).
Aluminium chlorohydrate
The aluminium
REFERENCES:
patent: 5411731 (1995-05-01), Tanaka et al.
patent: 5442048 (1995-08-01), Meister et al.
W. Umbach, "Kosmetik", Thieme Verlag, p. 141, et seq., New York (1998).
Gesslein, et al., HAPPI 27: 57 (1990).
O. Skaugrud, Drug Cosm. Ind. 148: 24 (May, 1991).
E. Onsoyen, et al., Seifen-Ole-Fette-Wachse 117: 633-37 (1991).
Tronnier, et al, J. Soc. Cosm. Chem. 24: 281-290 (1973).
Graham, et al., J. Pharm. Pharmacol. 26: 531-534 (1974).
Lehmann Rudolf
Panzer Claudia
Wachter Rolf
Dodson Shelley A.
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Szoke Ernest G.
Trzaska Steven J.
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