Deodorizing preparations

Details Deodorizing preparations Deodorizing preparations

1999-04-16

2000-04-04

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Anti-perspirants or perspiration deodorants

424 68, 424400, 424401, A61K 732, A61K 738, A61K 700

Patent

active

060457856

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

This invention relates to deodorizing formulations containing sterol sulfates, aluminium chlorohydrate, esterase inhibitors and bactericidal/bacteriostatic agents and to the use of sterol sulfates for the production of cosmetic formulations, for example deodorizing formulations.


DISCUSSION OF THE RELATED ART

In the field of personal hygiene, deodorants are used to eliminate troublesome body odors. Body odors are formed by the bacterial decomposition of basically odorless perspiration, particularly in the damp underarm regions or under similar conditions favorable to microorganism growth. Body odors can be masked by suitable perfumes. They can also be controlled by using formulations which inhibit the actual secretion of perspiration or its decomposition (so-called antihydrotics, antiperspirants or antitranspirants). Typical examples of such substances are aluminium compounds, such as aluminium sulfate or aluminium chlorohydrate, zinc salts and citric acid compounds. An overview of these agents was published, for example, in Umbach (Ed.), "Kosmetik", pages 141 et seq., Thieme Verlag, Stuttgart, 1988.
However, it is clear from everyday living that the problem of odor inhibition, particularly in heat or in the event of bodily activity, has by no means been completely solved. Commercial products are unable permanently to suppress the secretion of perspiration or the formation of odors. Instead, their inhibiting effect is of limited duration and is also dependent on the extent to which perspiration is secreted. Accordingly, there is a constant need for improved products which minimize the secretion of perspiration and reduce the formation of body odors and which, at the same time, show increased dermatological compatibility, i.e. reduced irritation potential towards particularly sensitive skin. The problem addressed by the present invention was to provide such products.


DESCRIPTION OF THE INVENTION

The present invention relates to deodorizing formulations containing
The use of aluminium chlorohydrates, esterase inhibitors (for example triethyl citrate) and bactericidal agents (for example chitosan) for the production of deodorizing and/or perspiration-inhibiting compositions is known from the prior art. It has surprisingly been found that sterol sulfates inhibit the activity of esterolytic enzymes, even in the lower ppm range, and that a synergistic deodorizing effect is obtained together with the components mentioned above. These sterol sulfates act selectively on serine esterases and serine proteases without impairing the biological equilibrium of the skin flora. At the same time, the use of sterol sulfates leads to an improvement in the skin-cosmetic compatibility of the products.
Sterol sulfates are known substances which may be prepared, for example, by sulfation of sterols with a complex of sulfur trioxide and pyridine in benzene [cf. J. Am. Chem. Soc. 63, 1259 (1941)]. Sterols--which may be used as starting materials for the production of sterol sulfates--are understood to be steroids which contain only a hydroxyl group at C-3 but no other functional groups. Formally, therefore, they are alcohols which would explain why this group of compounds is sometimes also referred to as sterols. Generally, sterols contain 27 to 30 carbon atoms and one double bond in the 5/6 position and optionally in the 7/8, 8/9 or other positions. Besides these unsaturated species, however, other suitable starting materials are the saturated compounds obtainable by hydrogenation. Typical examples of suitable sterol sulfates are those based on zoosterols, for example animal cholesterol, lanosterols from wool fat, spongosterols from sponges or stellasterols from starfish. However, phytosterol sulfates, for example those based on ergosterols, campesterols, stigmasterols and sitosterols, are preferably used by virtue of the lighter color of the sulfation products.
The aluminium chlorohydrates of component (b1) are colorless hygroscopic crystals which readily coalesce in air and which accumulate during th

REFERENCES:
patent: 4450151 (1984-05-01), Shinozawa

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