Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Reexamination Certificate
2000-01-28
2001-08-21
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
C424S068000, C424S401000
Reexamination Certificate
active
06277359
ABSTRACT:
BACKGROUND OF THE INVENTION
This invention relates to deodorizing formulations containing dimer alcohol-bis- and trimer alcohol-tris-sulfates and -ether sulfates, aluminium chlorohydrate, esterase inhibitors and/or bactericidal or bacteriostatic agents and to the use of dimer alcohol-bis- and trimer alcohol-tris-sulfates and -ether sulfates for the production of cosmetic formulations, for example deodorizing formulations.
In the field of personal hygiene, deodorants are used to eliminate troublesome body odors. Body odors are formed by the bacterial decomposition of basically odorless perspiration, particularly in the damp underarm regions or under similar conditions favorable to microorganism growth. Body odors can be masked by suitable perfumes. They can also be controlled by using formulations which inhibit the actual secretion of perspiration or its decomposition (so-called antihydrotics, antiperspirants or antitranspirants). Typical examples of such substances are aluminium compounds, such as aluminium sulfate or aluminium chlorohydrate, zinc salts and citric acid compounds. An overview of these agents was published, for example, in Umbach (Ed.), “Kosmetik”, pages 141 et seq., Thieme Veriag, Stuttgart, 1988.
However, it is clear from everyday living that the problem of odor inhibition, particularly in heat or in the event of bodily activity, has by no means been completely solved. Commercial products are unable permanently to suppress the secretion of perspiration or the formation of odors. Instead, their inhibiting effect is of limited duration and is also dependent on the extent to which perspiration is secreted. Accordingly, there is a constant need for improved products which minimize the secretion of perspiration and reduce the formation of body odors and which, at the same time, show increased dermatological compatibility, i.e. reduced irritation potential towards particularly sensitive skin. The problem addressed by the present invention was to provide such products.
DESCRIPTION OF THE INVENTION
The present invention relates to deodorizing formulations containing
(a) dimer alcohol-bis- and trimer alcohol-tris-sulfates and/or -ether sulfates,
(b) aluminium chlorohydrate,
(c) esterase inhibitors and/or
(d) bactericidal or bacteriostatic agents.
The present invention also relates to the use of dimer alcohol-bis- and trimer alcohol-tris-sulfates and/or -ether sulfates for the production of cosmetic formulations such as, for example, deodorizing formulations.
The use of aluminium chlorohydrates, esterase inhibitors (for example triethyl citrate) and bactericidal agents (for example chitosan) for the production of deodorizing and/or perspiration-inhibiting compositions is known from the prior art. It has surprisingly been found that dimer alcohol-bis- and trimer alcohol-tris-sulfates and/or -ether sulfates inhibit the activity of esterolytic enzymes, even in the lower ppm range, and that a synergistic deodorizing effect is obtained together with the components mentioned above. These surfactants act selectively on serine esterases and serine proteases without impairing the biological equilibrium of the skin flora. At the same time, the use of dimer alcohol-bis- and trimer alcohol-tris-sulfates and/or -ether sulfates leads to an improvement in the skin-cosmetic compatibility of the products so that they may also be used in cosmetic formulations.
Dimer Alcohol-bis- and Trimer Alcohol-tris-sulfates and/or -ether Sulfates
The dimer alcohol-bis- and trimer alcohol-tris-sulfates and/or -ether sulfates according to the invention, which form component (a), are so-called gemini surfactants. They are distinguished by two anionic sulfate groups which are generally arranged at a distance of about 18 carbon atoms which guarantees that the two hydrophilic groups are able to act independently of one another.
These surfactants are produced in known manner (cf. DE 19503061 A1) by sulfation of dimer and/or trimer alcohols or addition products thereof with alkylene oxides at 25 to 70° C. and subsequent neutralization with a base (pH range 6.5 to 8.5). After neutralization, the sulfation products can be bleached in known manner by addition of hydrogen peroxide or sodium hypochlorite.
The dimer and trimer alcohols are commercially available compounds and may be obtained, for example, from dimer and trimer fatty acids which are generally mixtures of acyclic and cyclic dicarboxylic acids containing on average 36 to 44 carbon atoms [cf. A. Hinze, Fette & Öle, 26, (1994)]. The corresponding alkoxylates, for example the ethoxylates and/or propoxylates, may be obtained in known manner by alkoxylation of the dimer and trimer alcohols with a degree of ethoxylation of 1 to 20 and preferably 2 to 10. Suitable sulfonating agents are, for example, sulfuric acid, oleum, chlorosulfonic acid, aminosulfonic acid and gaseous sulfur trioxide. The neutralization step is carried out with bases, such as alkali metal hydroxides, alkaline earth metal oxides and hydroxides, ammonia, alkanolamines and
Aluminium Chlorohydrate
The aluminium chlorohydrates of component (b) are colorless hygroscopic crystals which readily coalesce in air and which accumulate during the concentration of aqueous aluminium chloride solutions by evaporation. Aluminium chlorohydrate is used for the production of antiperspirant and deodorizing formulations and probably acts by contracting or blocking the sweat glands by protein precipitation and/or removal of moisture [cf. J. Soc. Cosm. Chem. 24, 281 (1973)]. An aluminium chlorohydrate which corresponds to the formula [Al
2
(OH)
5
Cl].2.5H
2
O is commercially available under the name of Locron® from Hoechst AG of Frankfurt, FRG. This aluminium chlorohydrate is particularly preferred for the purposes of the invention [cf. J. Pharm. Pharmacol. 26 531 (1975)].
Esterase Inhibitors
When perspiration is present in and around the underarm region, extracellular enzymes—esterases, preferably proteases and/or lipases—which cleave esters and thus emit odor-forming substances are activated by bacteria. The esterase inhibitors of component (c), preferably trialkyl citrates, such as trimethyl citrate, tripropyl citrate, tributyl citrate and, in particular, triethyl citrate (Hydagen® CAT, Henkel KGaA, Düsseldorf, FRG), inhibit the enzyme activity and thus reduce odor formation. The free acid is probably released by the cleavage of the citric acid ester, reducing the pH value on the skin to such an extent that the enzymes are inactivated by acylation. Other substances suitable for use as esterase inhibitors are dicarboxylic acids and esters thereof such as, for example, glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid, adipic monoethyl ester, adipic acid diethyl ester, malonic acid and malonic acid diethyl ester, hydroxycarboxylic acids and esters thereof such as, for example, citric acid, malic acid, tartaric acid or tartaric acid diethyl ester.
Bactericides or Bacteriostatic Agents
Bactericides or bacteriostatic agents (component (d)), which influence the germ flora and kill off or inhibit the growth of perspiration-decomposing bacteria, may also be present in the formulations. Typical examples are, in particular, chitosan and phenoxyethanol. 5-Chloro-2-(2,4-dichlorophenoxy)-phenol, which is marketed by Ciba-Geigy of Basel, Switzerland under the name of Irgasan®, has also proved to be particularly effective.
COMMERCIAL APPLICATIONS
Dimer alcohol-bis-and trimer alcohol-tris-sulfates and ether sulfates have proved to be enzyme-inhibiting for the described application. Accordingly, the present invention relates to their use for the production of cosmetic formulations such as, for example, hair shampoos, hair lotions, foam baths, creams, gels or lotions.
They may be used in particular for the production of deodorizing formulations either on their own or together with other deodorizing agents, such as aluminium chlorohydrates, other esterase inhibitors and/or bactericidal or bacteriostatic agents.
In one preferred embodiment of the in
Biermann Manfred
Maurer Karl-Heinz
Raths Hans-Christian
Cognis Deutschland GmbH
Dodson Shelley A.
Drach John E.
George Konata M.
Trzaska Steven J.
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