Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Patent
1996-12-09
1999-04-20
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
424401, 514739, A61K 732
Patent
active
058956433
DESCRIPTION:
BRIEF SUMMARY
The invention relates to deodorizing and antimicrobial compositions for use in cosmetic or topical Formulations, in particular deodorizing cosmetic compositions.
Deodorizing cosmetic compositions are employed in particular for suppressing unpleasant body odour which forms as a result of the formation of intensely smelling decomposition products due to the action of certain skin bacteria on the initially largely odourless apocrine perspiration under the influence of heat and moisture.
In addition to molecules which absorb odours, two main classes of products are currently known for combating bad odours resulting from perspiration.
On the one hand, antiperspirant agents based on products which suppress or severely inhibit the formation of perspiration, such as astringents based on aluminium salts, and in particular based on aluminium hydroxychloride, are known. The formation of bad odours can be suppressed with these agents in that their immediate cause, that is to say the development of perspiration through the epidermis, is suppressed (cf. DE-A 21 37 926). In contrast to these antiperspirants, cosmetic compositions having a deodorizing action are a class of compositions which, although they have no action or only a slight action on the volume of perspiration, on the basis of their bactericidal action destroy the bacteria which lead to decomposition of the perspiration. These include compositions having a content of antimicrobial substances. Among the compounds having such properties, for example, phenol derivatives with and without halogen substituents, organic mercury compounds, quaternary ammonium compounds, such as Cequartyl.RTM. or certain ion exchangers or metal chelates of 1,3-diketones, as well as derivatives of amino acids having a disinfecting action have become known.
Phenyl hydroxyalkyl ethers, in particular the compound known by the name phenoxyethanol, have furthermore been employed as preservatives on the basis of their bactericidal and fungicidal actions on a number of microorganisms. Phenoxyethanol is active and completely non-toxic, above all in an acid and neutral medium, but also in an alkaline medium. It provides adequate protection even at low concentrations. Because of its neutral smell, it rapidly found acceptance in the pharmaceuticals and cosmetics industry. However, its action is chiefly directed against Gram-negative bacteria.
From the chemical aspect, phenoxyethanol is largely inert when used. It is a colourless, slightly viscous liquid with a weak, pleasant smell and an astringent taste, and is miscible with acetone, ethyl alcohol and glycerol and soluble in water (1:45) and fats, for example olive oil and ground nut oil (1:50).
However, the solubility of phenoxyethanol in water is low and is not adequate for some preservation purposes.
Phenoxyethanol, which is adequately described in the literature, has been detected in nature in tropical fruits, in Cichorium endivia and in green tea (Camellia sinensis). It has a mild, rose-like fragrance and is also employed as a fixative for perfume compositions.
It is also known from GB-B 11 55 789 to employ certain phenyl ethers as antibacterial agents in cleansing compositions for the skin. Substituted phenyl ethers are moreover used as antibacterial agents (cf. DE Offenlegungsschrift 16 42 057).
In a further development of the principle described above, attempts have therefore been made additionally to use the antimicrobial properties of certain odoriferous substances, essential oils or other perfume constituents and to employ these as antimicrobial and deodorizing active compounds in deodorizing perfume compositions. DE-A 27 28 921 and DE-A 33 15 058 describe the natural substance farnesol (for example 2-trans,6-trans-3,7,11-trimethyldodeca-2,6,10-trien-1-ol) and its 3 synthetic isomers as such an antimicrobially active substance which severely inhibits the growth of odour-forming bacteria on the skin without greatly changing the overall bacterial flora of the skin. A disadvantage here is, however, that when used as a deodorizing, antim
REFERENCES:
patent: 4921694 (1990-05-01), Hoppe et al.
patent: 5690919 (1997-11-01), Rockl et al.
Hoppe Udo
Liebl Martina
Sauermann Gerhard
Traupe Bernd
Wolf Florian
Beiersdorf AG
Dodson Shelley A.
Williamson Michael A.
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