Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Reexamination Certificate
2001-10-09
2003-01-07
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
C424S401000, C424S405000, C424SDIG005
Reexamination Certificate
active
06503490
ABSTRACT:
FIELD OF INVENTION
This invention relates to the field of anti-microbial and deodorant compositions. In addition, this invention is concerned with achieving a deodorancy benefit upon the surface of the human body and in close environs thereto. The compositions and methods involved utilise transition metal chelators and particular phenolic or enolic compounds. When used on the human body, the compositions and methods of the invention are generally of greatest benefit when used on the most malodorous areas of the body, for example the underarm areas or feet.
BACKGROUND
Anti-microbial and deodorant compositions may function by a variety of means. When used upon the human body, such compositions may function by significantly reducing microbial numbers either by reducing perspiration or by directly affecting the micro-organisms on the body surface as represented by skin. It is with this latter mechanism of action that this invention is largely concerned.
Most anti-microbial and deodorant compositions reduce the number of viable micro-organisms on the surface of the skin. It is well known that sweat is usually odourless until it has been degraded by the skin microflora. Typical deodorants include ethanol and triclosan (2,4,4′-trichloro,2′-hydroxy-diphenyl ether) which is a well known anti-microbial agent. However, the deodorising effect obtained with such deodorants wears off with the passage of time and the microflora progressively recover their numbers. There is, therefore, a continuing requirement for effective and long lasting deodorant compositions on the market. Hence, the problem to be solved is not simply reducing microbial numbers on the body surface; equally important is maintaining low microbial numbers (particularly low bacterial numbers) on the body surface (particularly in the most malodorous areas, eg. the axillae).
Deodorant compositions comprising chelators are described in our recent British patent applications GB 0001133.8, GB 0001132.0, GB 0001131.2, GB 0001130.4, and GB 0001129.6, all of which are incorporated herein by reference. These patent applications disclose the hypothesis that certain chelators can effectively inhibit the up-take of essential transition metal ion nutrients by microbes on the skin surface, thereby minimising their growth. Other references to deodorant compositions comprising transition metal chelating agents are given in these patent applications, the most relevant of which are detailed below.
U.S. Pat. No. 4,356,190 (Personal Products Co.) discloses the use of selected aminopolycarboxylic acid compounds for inhibiting the formation of short chain fatty acids by Corynebacterium on the skin surface.
WO 97/02010 (Procter and Gamble Co.) discloses the use of chelators selected from the succinic acid, glutaric acid, and phosphonic acid classes as bactericidal compounds.
WO 97/44006 (Ciba Speciality Chemicals Holding, Inc.) claims the use of nitrogen—containing complexing agents for the anti-microbial treatment of the skin and of textile fibre materials.
WO 97/01360 (Concat Ltd.) claims a method of inhibiting bacterial growth using particular substituted polyaza chelator compounds.
In the course of the present investigations, we have observed that particularly long-lasting malodour control is maintained by the combined use of a transition metal chelator and a phenolic or enolic transferrin dissociation promoter.
The presence of transferrin in mammalian sweat, including human sweat, is well-established (see, for example, S. E. Lind,
Corros. Sci.,
1972, 12(9), 749). It is also known that certain bacteria make use of the iron bound to transferrin by means of sophisticated iron-scavenging systems including siderophores and cell surface receptors for transferrin (E.Griffiths and P.Williams,
The Iron Uptake Systems of Pathogenic Bacteria, Fungi and Protozoa in Iron and Infection
(editors: S. S.Bullen and E.Griffiths), 2
nd
Edn., 1999, John Wiley and Sons, pp 87-212). Certain chemical agents, in addition to bacterial siderophores, are capable of promoting the liberation of iron from transferrin and it is with the use of particular transferrin dissociation promoters of this type that this invention is largely concerned. In particular, this invention is concerned with phenolic or enolic transferrin dissociation promoters that operate by aiding the reduction of iron(III) bound to transferrin to iron(II), which binds less strongly to transferrin (see N.Kojima and G. W.Bates,
J. Biol. Chem.,
1979, 254(18), 8847).
Certain transition metal chelators and particular agents that can serve as transferrin dissociation promoters are disclosed in prior documents as preservative/antioxidant systems for cosmetic compositions. However, the amounts disclosed are typically very small and, in addition, the transferrin dissociation promoters disclosed in these documents are not recognised as such. A typical example is EP 979,644 (ITBR-N) which discloses a deodorant composition comprising 0.05% butylated hydroxytoluene (BHT) and 0.05% disodium ethylenediaminetetraacetic acid (Na
2
EDTA).
SUMMARY OF THE INVENTION
We have surprisingly discovered that by the combined use of effective amounts of a transition metal chelator and particular phenolic or enolic compounds, excellent anti-microbial benefits and deodorancy benefits can be achieved.
Thus, according to a first aspect of the present invention, there is provided a method of achieving an anti-microbial and deodorancy benefit comprising the application to the human body or to an article wearable in close proximity thereto, of an anti-microbial product comprising effective amounts of a transition metal chelator and a phenolic or enolic compound that is (a) a transferrin dissociation promoter that operates by aiding the reduction of iron(III) bound to transferrin to iron(II) and/or (b) an anti-oxidant comprising a tert-butylphenol group.
In the above aspect of the present invention, ‘effective amounts’ refer to amounts that are sufficient for a significant deodorancy benefit to be observed 24 hours after application of the anti-microbial product. ‘Application’ involves deposition of both of the active components upon the substrate being treated.
According to a second aspect of the present invention, there is provided an anti-microbial deodorant composition for use on the human body comprising at least 0.35% by weight of a transition metal chelator and at least 0.05% by weight of a phenolic or enolic compound that is (a) a transferrin dissociation promoter that operates by aiding the reduction of iron(III) bound to transferrin to iron(II) and/or (b) an anti-oxidant comprising a tert-butylphenol group, wherein the weight percentages exclude any volatile propellant present.
According to a third aspect of the present invention, there is provided a method for the manufacture of a deodorant composition for use on the human body, comprising the formation of a mixture of at least 0.35% by weight of a transition metal chelator and at least 0.05% by weight of a phenolic or enolic compound that is (a) a transferrin dissociation promoter that operates by aiding the reduction of iron(III) bound to transferrin to iron(II) and/or (b) an anti-oxidant comprising a tert-butylphenol group, wherein the weight percentages exclude any volatile propellant present.
DETAILED DESCRIPTION
Excellent anti-microbial and deodorancy benefits are found on combined use of a transition metal chelator and a phenolic or enolic compound as described herein. Without wishing to be bound by theory, it is hypothesised that the transition metal chelator contributes to the benefits attained by inhibiting the up-take of essential transition metal ion nutrients, in particular iron(III), by microbes on the skin surface, thereby minimising their growth. It is further hypothesised that the phenolic or enolic compound contributes by interfering with biochemical pathways by which microbes on the skin surface extract iron(III) from the human iron carrier protein complex transferrin.
In employing a method according to the first aspect of this invention, it
Johnson Paula Ann
Landa Andrew Sjaak
Makin Stephen Anthony
McKay Victoria Anne
Dodson Shelley A.
Stein Kevin J.
Unilever Home & Personal Care USA , division of Conopco, Inc.
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