Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Patent
1996-08-15
1998-07-07
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
424400, 424401, 424404, A61K 732, A61K 700, A01N 2502
Patent
active
057764530
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a product for preventing and controlling bad smells caused by human perspiration, e.g. smells coupled with perspiring (sweaty) feet. Such smells are caused by decomposition products produced by bacteria. Such decomposition products of human perspiration fluid may be bad smelling acids.
It is an object of the present invention to provide a product which is effective for combatting cause and effect of such decomposition products.
A further object of the invention is to provide products as mentioned in the preamble in the form which is easy to use.
According to the invention these objects are realized by a product as mentioned in the preamble, which product contains at least one compound (a) which yields an aldehyde, in particular formaldehyde, under the influence of human perspiration fluid.
In general compound (a) consists of hexamethylene tetramine or any other cyclic formaldehyde ammonia or urea condensation product, or polymeric formaldehyde compound like para-formaldehyde and trioxane.
Preferably, compound (a) is selected from hexamethylene tetramine (HMTA), paraformaldehyde and trioxane. HMTA is especially preferred.
In the product according to the invention compound (a), e.g. HMTA, is present in an amount of 0.005-1 wt. %, preferably 0.01-0.15 wt. %, calculated on the weight of the total product. If the amount of compound (a) is less than 0.005 wt. % . the effect of the product is too low. Higher amounts than 1 wt. % may be used, but this is not 30 necessary in e.g. liquid preparations such as foot sprays.
The product according to the invention may be present in various forms, i.e. in the form of a cosmetic preparation or in other forms, which are illustrated hereinbelow.
According to a preferred embodiment the product is present in a liquid form, e.g. in the form of a clear solution. Such liquid preparations may contain usual additives, solvents, and/or diluents. Preferably such liquid preparation contains one or more physiologically acceptable solvents and/or diluents selected from water and alcohols, such as ethanol, isopropanol and glycerol.
According to the preferred embodiment the invention provides a preparation destined for the treatment of feet, which composition contains compound (a), e.g. HMTA, camphor as an additive and water and ethanol as solvents.
In case the product of the invention contains e.g. HMTA, the aimed effect seems to be based on the slow production of formaldehyde from HMTA under the influence of organic acids present in perspiration fluid or formed by virtue of bacterial action (e.g. butyric acid).
The effect of the composition of the invention can be increased by adding formaldehyde and/or camphor. Camphor is a disinfectant and strengthens the action of the product. Furthermore camphor has a hardening effect on the skin of the feet providing a drier feeling of the feet.
According to a special embodiment of the invention the aldehyde and/or camphor are present in amounts of 0.001-0.05 wt. % and 0.1-30 wt. % respectively, calculated on the weight of the total product.
If in the product of the invention glycerol is used, then the amount thereof will be preferably 1-15 wt. %, calculated on the weight of the total product.
An example of a composition according to the invention, suitable for application on the human skin, in particular feet, comprises for example the total product. Of course, the total amount of the various components cannot exceed 100 wt. %.
As mentioned in the above the product of the invention may be present in the form of a clear solution. Such a solution can be easily atomized with or without an added propellant and directly applied onto e.g. feet, but also on socks, insoles, shoes and the like. Of course, the liquid composition according to the invention can be in any suitable cosmetic form, which is generally known for antiperspiration agents.
The invention also relates to a container containing the product as described in the above, preferably in the form of a clear solution, which container is provided with means to atom
REFERENCES:
Database EPODOC, CN-A-1062838, Jul. 22, 1992.
STN International, Karlsruhe, File Chemical Abstracts, AN=122:273803 & CN,A,1088084, Jun. 22, 1994.
Rote Liste. Bundesverband der Pharmazeutischen Industrie E.V., Editio Cantor, Aulendorf, 1993, No. 31218 "Antihydral".
Reynolds, J.E.F., Martindale, The Extra Pharmacopoeia, 29th Edition, 1989, The Pharmaceutical Press, London, pp. 246-247.
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