Dentin chondrogenic inductive agent

Details Dentin chondrogenic inductive agent Dentin chondrogenic inductive agent

1988-09-06

1990-06-19

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins from mammals or birds

Bones; tendons; teeth; cartilage

530300, A61K 3712, A61K 3512, A01N 6302, C07K 328

Patent

active

049354973

ABSTRACT:
A cartilage-inducing factor has been isolated from dentin and characterized as a polypeptide having an apparent molecular weight of 6,000 to 8,500, an isoelectric pH of from 4.5 to 6.5, and, biologically, as being capable of inducing muscle fibroblast cells to produce cartilage-specific proteoglycan and Type II collagen.

REFERENCES:
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4774228 (1988-09-01), Seyedin et al.
patent: 4774322 (1988-09-01), Seyedin et al.

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