Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1997-04-03
2000-12-12
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 49, 424 57, A61K 716, A61K 718
Patent
active
061594490
ABSTRACT:
A dentifrice product substantially free of water-soluble inorganic orthophosphates and capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth, contains (A) a discrete cationic part containing at least one water-soluble and/or partially water-soluble calcium compound and a fluoride-protecting amount of at least one water-soluble and/or partially water-soluble magnesium compound, and (B) a discrete anionic part containing at least one water-soluble fluoride compound. The cationic and anionic parts are disposed separate from one another in the product and are simultaneously releasable from the product. The cationic and anionic parts each have a pH in water such that a mixed aqueous composition formed by mixing the cationic and anionic parts with (i) saliva or (ii) water and saliva has a pH of from about 4.0 to about 10.0. The mixed aqueous composition simultaneously applies the cationic and anionic parts to the tooth surfaces being treated. Dentifrice products containing a minor amount of at least one water-soluble inorganic orthophosphate compound in the anionic part and dentifrice products which are substantially devoid of water-soluble inorganic orthophosphate compounds but which may contain a substantially water-insoluble phosphate compound, e.g., as an abrasive and/or polishing agent, are also provided.
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Usen Norman
Winston Anthony E.
Enamelon Inc.
Frenkel Stuart D.
Rose Shep K.
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