Drug – bio-affecting and body treating compositions – Dentifrices – Phosphate compound containing
Patent
1993-10-26
1997-03-18
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Dentifrices
Phosphate compound containing
424 49, 424 52, 423335, 423338, 106 35, 106492, 51308, A61K 716, A61K 718, C01B 3312, C04B 1404
Patent
active
056120206
ABSTRACT:
Novel silica particulates especially adapted for formulation to dentifrice compositions exhibit unique physical and chemical properties. In one embodiment, silica particulates have a unique surface chemistry, as to be at least 50% compatible with zinc values, and have a number of OH functions, expressed as OH
m.sup.2, of at most 15 and a zero charge point (PZC) of from 3 to 6.5. In a second embodiment, particulates have a surface chemistry as to be at least 65%, and preferably at least 90% compatible with guanidine values, notably chlorhexidine, and acidity function thereof, Ho, of at least 3.3. In a third embodiment, silica particulates are compatible with organic amines, and have a pH, in aqueous suspension, which varies according to the equations pH.ltoreq.7.5-0.7 log(C) and pH.gtoreq.5.0-0.5 log(C) and which also varies as a function of the electrical conductivity thereof, according to the equations pH.ltoreq.8.5-0.4 log(D) and pH.gtoreq.7.0-0.6 log(D) wherein (C) represents the weight concentration of said silica suspension, expressed % SiO.sub.2 and (D) represents the electrical conductivity of such aqueous silica suspension expressed in microsiemens.multidot.cm.sup.-1. In a fourth embodiment, novel silica particulates are compatible with such metal cations as zinc, tin, strontium, and the like, as well as with the fluorides, and have a unique surface chemistry such that the number of OH.sup.- functions thereof, expressed in OH.sup.-
m.sup.2, is equal to or less than 10, and also have a zero charge point (ZCP) ranging from 3 to 6.5 and a pH, in aqueous suspension, which varies as a function of the electrical conductivity thereof according to the equation pH=b-a log (D) in which a is a constant equal to or less than 0.6; b is a constant equal to or less than 8.5; and (D) represents the electrical conductivity of such aqueous silica suspension, expressed in microsiemens.multidot.cm.sup.-1.
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Azpuru Carlos A.
Rhone-Poulenc Chimie
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