Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1992-06-19
1994-02-15
Michl, Paul R.
Drug, bio-affecting and body treating compositions
Dentifrices
424 52, 424 57, 51308, 106 35, 423335, A61K 716, A61K 718, C09K 314, C01B 3312
Patent
active
052864782
ABSTRACT:
Novel silica particulates especially adapted for formulation to dentifrice compositions exhibit unique physical and chemical properties. In one embodiment, silica particulates have a unique surface chemistry as to be at least 50% compatible with zinc values, and have a number of OH functions, expressed as OH
m.sup.2, of at most 15 and a zero charge point (PZC) of from 3 to 6.5. In a second embodiment, particulates have a surface chemistry as to be at least 65%, and preferably at least 90% compatible with guanidine values, notably chlorhexidine, and acidity function thereof, Ho, of at least 3.3. In a third embodiment, silica particulates are compatible with organic amines, and have a pH, in aqueous suspension, which varies according to the equations pH.ltoreq.7.5-0.7 log(C) and pH.gtoreq.5.0-0.5 log(C) and which also varies as a function of the electrical conductivity thereof, according to the equations pH.ltoreq.8.5-0.4 log(D) and pH.gtoreq.7.0-0.6 log(D) wherein (C) represents the weight concentration of said silica suspension, expressed % SiO.sub.2 and (D) represents the electrical conductivity of such aqueous silica suspension expressed in microsiemens.multidot.cm.sup.-1. In a fourth embodiment, novel silica particulates are compatible with such metal cations as zinc, tin, strontium, and the like, as well as with the fluorides, and have a unique surface chemistry such that the number of OH.sup.- functions thereof, expressed in OH.sup.-
m.sup.2, is equal to or less than 10, and also have a zero charge point (ZCP) ranging from 3 to 6.5 and a pH, in aqueous suspension, which varies as a function of the electrical conductivity thereof according to the equation pH=b-a log (D) in which a is a constant equal to or less than 0.6; b is a constant equal to or less than 8.5; and (D) represents the electrical conductivity of such aqueous silica suspension, expressed in microsiemens.multidot.cm.sup.-1
REFERENCES:
patent: 3070426 (1962-12-01), Winyall
patent: 3794712 (1974-02-01), Aboutboul et al.
patent: 3800031 (1974-03-01), Sale et al.
patent: 3803046 (1974-04-01), Winyall et al.
patent: 3893840 (1975-07-01), Wason
patent: 3988162 (1976-10-01), Wason
patent: 4015996 (1977-04-01), Wason
patent: 4040858 (1977-08-01), Wason
patent: 4045240 (1977-08-01), Wason et al.
patent: 4049781 (1977-09-01), Acker et al.
patent: 4144321 (1979-03-01), Wason
patent: 4191742 (1980-03-01), Wason et al.
patent: 4216113 (1980-08-01), Winyall
patent: 4251281 (1981-02-01), Machurat et al.
patent: 4272509 (1981-06-01), Wason
patent: 4279766 (1981-07-01), Joubert et al.
patent: 4331706 (1982-05-01), Kindrick
patent: 4340583 (1982-07-01), Wason
patent: 4422880 (1983-12-01), Wason et al.
patent: 4562065 (1985-12-01), Hayes et al.
patent: 4562066 (1991-08-01), Hayes et al.
patent: 4581292 (1986-04-01), Shinpo et al.
patent: 4590052 (1986-05-01), Chevallier et al.
patent: 4676964 (1987-06-01), Seki et al.
patent: 4704425 (1987-11-01), Lagarde et al.
patent: 4874594 (1989-10-01), Chevallier
patent: 4956167 (1990-09-01), Aldcroft et al.
patent: 4973462 (1990-11-01), Akira et al.
Azpuru C.
Michl Paul R.
Rhone-Poulenc Chimie
LandOfFree
Dentifrice-compatible silica particulates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dentifrice-compatible silica particulates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dentifrice-compatible silica particulates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1204990