Dental prophylaxis containing alkylamine fluorophosphates

Details Dental prophylaxis containing alkylamine fluorophosphates Dental prophylaxis containing alkylamine fluorophosphates

1975-10-20

1977-03-08

Gotts, Lewis

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

260583R, 260583P, A61K 718

Patent

active

040113108

ABSTRACT:
Novel alkylamine fluorophosphates of the formula: ##STR1## wherein R is a linear or branched alkyl group containing 1-20 carbon atoms; R.sub.1 is lower alkyl or hydrogen, R.sub.2 is alkyl or hydrogen; X is 1 or 2; Y is 1 when X=1; Y is 1 or 2 when X=2; m and n are positive whole integers whose sum is 3. When R, R.sub.1 and R.sub.2 are alkyl they can be substituted with an hydroxy group. The novel fluorophosphates have been found to be effective in reducing the acid solubility of tooth enamel.

REFERENCES:
patent: 2876166 (1959-03-01), Nebergall
Chem. Abstracts, vol. 76, 1972, paragraph 125934h, Mathey et al., "Direct Fluorination of Phosphoramides".

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