Dental products comprising bone growth enhancing peptide

Details Dental products comprising bone growth enhancing peptide Dental products comprising bone growth enhancing peptide

2006-07-18

2006-07-18

Weber, Jon (Department: 1654)

Drug, bio-affecting and body treating compositions

Dentifrices

C424S050000, C530S324000, C530S326000, C530S328000, C530S350000, C514S002600, C514S012200, C514S014800, C514S900000, C514S901000

Reexamination Certificate

active

07078021

ABSTRACT:
Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.

REFERENCES:
patent: 5407664 (1995-04-01), Konopa
patent: 6027592 (2000-02-01), Tseng et al.
patent: 6045780 (2000-04-01), Bixler et al.
patent: 6673900 (2004-01-01), Rowe
patent: 6790639 (2004-09-01), Brown et al.
patent: 6911425 (2005-06-01), Kumagai et al.
patent: 4-74132 (1992-03-01), None
patent: 4-506511 (1992-11-01), None
patent: 11-506672 (1999-06-01), None
patent: 11-318498 (1999-11-01), None
patent: 2002-500898 (2002-01-01), None
patent: 2002-512018 (2002-04-01), None
patent: WO 99/08730 (1999-02-01), None
patent: WO 99/60017 (1999-11-01), None
patent: WO 02/05836 (2002-01-01), None
Fisher et al., “Inhibition of osteoclastic bone resorption in vivo by echistatin an—arginyl-clycyl-aspartyl- (RGD)-containing protein”Endocrinology, 132(3):1411-1413 ((1993).
Horton et al., “Arg-Gly-Asp (RGD) Peptides and the Anti-Vitronectin Receptor Antibody 23C6 Inhibit Dentine Resorption and Cell Spreading by Osteclasts”Experimental Cell Research915:368-375 (1991).
Rowe “The PEX Gene: Its Role in X-Linked Rickets, Osteomalacia, and Bone Mineral Metabolism”Experimental Nephrology5:355-363 (1997).
Hayashibara et al., “A Synthetic Peptide Fragment of Human MEPE Stimulates New Bone Formation In Vitro and In Vivo”Journal of Bone and Mineral Resesarch19(3):455-462 (2004).
George et al., “Characterization of a Novel Dentin Matrix Acidic Phosphorprotein”J. Biol. Chem. 268(17):12624-12630 (1993).
Gronowicz et al., “Synthetic Peptide Containing Arg-Gly-Asp Inhibits Bone Formation and Resorption in a Mineralizing Organ Culture System of Fetal Rat Parietal Bones”J. Bone and Mineral Res. 9(2):193-201 (1994).
Rowe et al., “MEPE, a New Gene Expressed in Bone Marrow and Tumors Causing Osteomalacia”Genomics67:54-68 (2000).
Stubbs et al., “Characterization of Native and Recombinant Bone Sialoprotein: Delineation of the Mineral-Binding and Cell Adhesion Domains and Structural Analysis of the RGD Domain”J. Bone and Mineral Res. 12(8):1210-1222 (1997).

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