Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof
Patent
1996-08-07
1999-03-09
Pak, John
Drug, bio-affecting and body treating compositions
Dentifrices
Ammonia, amine, or derivative thereof
424 49, 424 55, 424 56, 424 57, 424401, 424678, 424682, 424710, 106 35, 4332281, A61K 600, A61K 722, A61K 910
Patent
active
058796630
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/JP95/02511 filed on Dec. 7, 1995.
1. Technical Field
This invention relates to a dental composition for occluding dentinal tubules. More specifically, it relates to a dental composition for relieving dentin hypersensitivity which induces pain sensations such as cold water, hot water, sweet, acidity and scraping pain sensations, by occluding dentinal tubules. Further, it relates to a dental composition which can be preserved stably and hygienically.
2. Background Art
Cold and heat pain sensations which are encountered when a tooth is brought into contact with air or water having different temperature from body temperature, sweet and acidity pain sensations which are encountered when sweet or acidic foods are taken, and a scraping pain sensation which is encountered when a tooth is brought into contact with a toothbrush or the like are caused by dentin hypersensitivity or pulpitis.
Pulpitis occurs as a result of inflammation caused by the infection of dental pulp with microbes, and its pain sensation continues for a relatively long period and can be treated only by removing the dental pulp.
Meanwhile, dentin hypersensitivity is a temporary induced pain sensation produced by physical or chemical stimulus. Therefore, a technique for easing the nerve cell of pulp whose reaction to stimulus is hypersensitive and a technique for excluding external stimulus to dental pulp have been proposed as a technique to overcome dentin hypersensitivity.
Pashley et al. propose in the specification of U.S. Pat. No. 4,057,621 a dental composition for relieving hypersensitivity which comprises an oxalate of a mono- or bi-substituted alkali metal or ammonium in a concentration range of from 2% by weight to saturation as well as a technique for relieving hypersensitivity.
In Japanese laid-open patent application publication No.4-217904, Imai et al. propose a dental treatment composition for forming a precipitate by sequentially applying two liquids A and B containing substances which produce a hardly soluble precipitate when mixed together. In this proposal, the liquid A is an aqueous solution containing 1 to 70% of a sodium salt, potassium salt or lithium salt of an inorganic or organic acid, and the liquid B is an aqueous solution containing 1 to 70% of a mixture containing at least one selected from the group consisting of chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead and tin, or calcium chloride, zinc chloride or strontium chloride.
Japanese laid-open patent application publication No.6-145020 proposes a crystal-forming primer for tooth, which comprises (A) a solution of 1 to 35% potassium oxalate, (B) aluminum oxalate and (C) 2% nitric acid.
Japanese laid-open patent application publication NO.5-70358 proposes a treatment agent for dentin hypersensitivity containing the following components (A) and (B). The component (A) is a colloidal zinc hydroxide and/or zinc oxide obtained by mixing a water-soluble zinc salt and a polyol phosphoric acid ester and/or a salt thereof in an aqueous medium, and the component (B) is a zinc salt of a polyol phosphoric acid ester.
In Japanese laid-open patent application publication No.5-255029, Imai et al. propose a dental treatment composition for forming a precipitate by sequentially applying two liquids A and B containing substances capable of producing fluoroapatite swiftly when mixed together. In this respect, the liquid A contains a water-soluble phosphoric acid salt in a concentration range of 1 to 30% and a water-soluble fluoride in an amount of 0.01 to 5% by weight, and the liquid B contains a water-soluble calcium salt in an amount of 1 to 30% by weight.
Japanese laid-open patent application publication No.6-116153 proposes a coating agent for relieving hypersensitivity which consists of a first liquid containing an aluminum compound and a second liquid containing at least one compound selected from the group consisting of phosphoric acid compounds, oxalic acid compounds, s
REFERENCES:
patent: 4057621 (1977-11-01), Pashley et al.
patent: 4159317 (1979-06-01), Onisi et al.
patent: 4538990 (1985-09-01), Pashley
patent: 5234971 (1993-08-01), Imai et al.
patent: 5538883 (1996-07-01), Nishimoto et al.
patent: 5554669 (1996-09-01), Nakabayashi et al.
patent: 5718885 (1998-02-01), Gingold et al.
patent: 5766328 (1998-06-01), Nakabayashi et al.
patent: 5780015 (1998-07-01), Fisher et al.
Derwent Abstract, accession number 93-172615; abstracting JP 5-105611 (Apr., 1993).
Arata Masami
Nakabayashi Nobuo
Saimi Yasukazu
Tanaka Harumi
Yamamoto Takashi
Nakabayashi Nobuo
Pak John
Sun Medical Co., Ltd.
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