Dental anti-plaque and anti-caries agent

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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Details

514775, 514835, 514900, 514901, 514959, 424 48, 424 49, 424401, 424464, A61K 3702, A61K 716, A61K 920, A61K 968

Patent

active

049944410

ABSTRACT:
Adhesion of bacteria in the buccal cavity which are responsible for the formation of dental plaque and caries is inhibited by kappa-caseino-glycopeptide compounds and desialylated derivaties thereof contained in compositions having a form suitable for being empolyed for treating the bacteria in the buccal cavity.

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patent: 4495176 (1985-01-01), Brule et al.
patent: 4579736 (1986-04-01), Hammond
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Pearce Chem. Abstr., vol. 93, No. 44093g (1980).
Neeser et al., Chem. Abstr., vol. 110, No. 72413z (1989).
Neeser, et al., Specific and Non specific Inhibition of Adhesion of Oral Actinomyces and Streptococci to Erythrocytes and Polystyrene by Caseinoglycopeptide Derivatives, Infection and Immunity, Dec. 1988, pp. 3201-3208, vol. 56, No. 12.
Brennan, et al., Lectin-Dependent Attachment of Actinomyces Raeslundiito Receptors of Epithelial Cells, Infect Immun., pp. 459-464, 1984.
Kolenbrander, Isolation and Characterization of Coaggregation-Defective Mutants of Actinomyces Viscosus, Actinomyces Naeslundii, & Steptococcus Sanguis. Infect Immun. 3:1, pp. 1200-1208, 9/1982.

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