Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1974-11-19
1976-07-13
Gotts, Lewis
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
32 15, A61K 718
Patent
active
039694992
ABSTRACT:
A composition of matter comprising a polymeric reaction product of a hydroxy terminated butadiene prepolymer having an average molecular weight of about 400 to 25,000 and containing 1 to 3 hydroxyl groups per molecule and a polyisocyanate reactant present in an amount to provide from 100 to 1200 percent excess isocyanate groups to hydroxyl groups or active hydrogen sites, and from 1 to 70 percent by weight of a compound containing a fluoride ion. In another, and preferred aspect of the invention, the polyisocyanate reactant is present in an amount to provide from 1.5 to 2.7 isocyanate groups for each hydroxyl group or active hydrogen site, the composition containing an aromatic polyol, such as N,N-bis(2-hydroxypropyl) aniline, and wherein the aromatic polyol comprises at least 42 percent but not more than 60 percent of the hydroxyl components. The compositions are especially useful as dental fissure sealants and as means of applying a fluoride to a tooth surface.
REFERENCES:
patent: 3427366 (1969-02-01), Verdol et al.
Galligan, et al. J. of Dent. Res., vol. 47, No. 4, pp. 629-632, Aug. 1968.
Lee, Jr. Henry L.
Orlowski Jan A.
Gotts Lewis
Lee Pharmaceuticals
Owens Cary
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