Density enhanced protein tyrosine phosphatases

Details Density enhanced protein tyrosine phosphatases Density enhanced protein tyrosine phosphatases

2007-03-27

2007-03-27

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

C424S143100, C435S326000

Reexamination Certificate

active

10390501

ABSTRACT:
Novel Type III density enhanced protein tyrosine phosphatases are disclosed and exemplified by human DEP-1 enzyme. Polynucleotides encoding huDEP-1 are disclosed, along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for DEP-1 are also disclosed as useful for modulating the biological activities of DEP-1.

REFERENCES:
patent: 5441880 (1995-08-01), Beach et al.
patent: 5512434 (1996-04-01), Aaronson et al.
patent: 6114140 (2000-09-01), Tonks et al.
patent: 6552169 (2003-04-01), Tonks et al.
patent: WO 94/03610 (1994-02-01), None
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Barnea et al., “Idnetification of a Carbonic Anyhydrase-Like Domain in the Extracellular Region of RPTP.gamma. Defines a New Subfamily of Receptor Tyrosine Phosphates,”Mol. Cell. Biol. 13:1497-1506, 1993.
Bork and Doolittle, “Proposed Acquisition of an Animal Protein Domain by Bacteria,”Proc. Natl. Acad. Sci. USA 89:8990-8994, 1992.
Brown-Shimer et al., “Effect of Protein Tyrosine Phosphate 1B Expression on Transformation by the Human neu Oncogene,”Cancer Res. 52:478-482, 1992.
Buzzi et al., “Differentiation-Induced Changes in Protein-Tyrosine Phosphatase . . . ,”Cancer Res. 52:4027-4035, 1992.
Capecchi, “Altering the Genome by Homologous Recombination,”Science 244:1288-1292, 1989.
Carr et al., “Association of the Type II cAMP-dependent Protein Kinase with a Human Thyroid RII-Anchoring Protein,”J. Biol. Chem. 267:13376-13382, 1992.
Carr and Scott, “Blotting and Bandshifting: Techniques for Studying Protein-Protein Interactions,”Trends in Biochemical Sci. 17:246-249, 1992.
Charbonneau and Tonks, “1002 Protein Phosphatases,”Ann. Rev. Cell Biol. 8:463-493, 1993.
Cool et al., “cDNA Isolated from a Human T-Cell Library Encodes a Member of the Protein-Tyrosine-Phosphatase Family,”Proc. Natl. Acad. Sci. USA 86:5257-5261, 1989.
Edelman and Crossin, “Cell Adhesion Molecules: Implications for a Molecular Histology,”Ann Rev. Biochem. 60:155-190, 1991.
Fields and Song, “A Novel Genetic System to Detech Protein-Protein Interactions,”Nature 340:245-246, 1989.
Fischer et al., “Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes,”Science 253:401-406, 1991.
Flint et al., “Multi-site Phosphorylation of the Protein Tyrosine Phosphatase, PTPIB: Identification of Cell Cycle Regulated and Phorbol Ester Stimulated Sites of Phosphorylation,”EMBO J. 12:1937-1946, 1993.
Frangioni et al., “The Nontransmembrani Tyrosine Phosphatase PTP-B1 Lacalizes to the Endoplasmic Reticulum Via its 35 Amino Acid C-Terminal Sequence,”Cell 68:545-560, 1992.
Gu et al., “Cloning and Expression of a Cytosolic Megakarycyte Protein-Tyrosine-Phosphatase with a Sequence Homology to Retinaldchyde-Binding Protein and Yeast SEC14p,”Proc. Natl. Acad. Sci. USA 89:2980-2984, 1992.
Honda et al., “Identification of Novel Protein-Tyrosine Phosphatases . . .,”Leukemia7(5):742-746, 1993.
Honda et al., “Molecular Cloning Characterization and Chromosomal Localization of a Novel Protein-Tyrosine Phosphatase HPTP.sub.1,”Blood 84(12):4186-4194, 1994.
Klarlund, “Transformation of Cells by an Inhibitor of Phosphatases Acting on Phosphotyrosine in Proteins,”Cell 41:707-717, 1985.
Kozak, “The Scanning Model for Translation: An Update,”J. Cell Biol. 108:229-241, 1989.
Krueger et al., “Structural Diversity and Evolution of Human Receptor-like Protein Tyrosine Phosphatases,”EMBO J. 9:3241-3252, 1990.
Leahy et al., “Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein,”Science 258:987-991, 1992.
Longo et al., “Leukocyte Common Antigen-Related Receptor-linked Tyrosine Phosphatase,”J. Biol. Chem. 268:26503-25611, 1993.
Main et al., “The Three Dimensional Structure of the Tenth Type III Module of Fibronectin an Insight into RGD-mediated Interactions,”Cell 71:671-678, 1992.
Matozaki et al., “Molecular Cloning of a Human Transmembrane-type Protein Tyrosine Phosphatase and its Expression in Gastrointestinal Cancers,”J. Biol. Chem. 269:2075-2081, 1994.
Pallen and Tong, “Elevation of Membrane Tyrosine Phosphatase Activity in Density-Dependent Growth-Arrested Fibroblasts,”Proc. Natl. Acad. Sci. USA 88:6996-7000, 1991.
Pingel and Thomas, “Evidence that the Leukocyte Common Antigen is Required for Antigen-Induced T Lymphocyte Proliferation,”Cell 58:1055-1065, 1989.
Rijksen et al., “Orthovanadate Both Mimics and Antagonizes the Transforming Growth Factor β Action on Normal Rat Kidney Cells,”J. Cell Physiol. 154:393-401, 1993.
Sambrook et al.,Molecular Cloning, CSH Laboratory Press, 1989, pp. 16.17-16.22.
Sambrook et al.,Molecular Cloning, CSH Laboratory Press, 1989, pp. 16.32-16.40.
Schultz et al., “Mutations at the Murine Motheaten Locus are within the Hematopoietic Cell Protein-Tyrosine Phosphatase (Hcph) Gene,”Cell 73:1445-1454, 1993.
Schwarzbauer, “Fibronectin: From Gene to Protein,”Curr. Opin. Cell. Biol. 3:786-791, 1991.
Scott and Smith, “Searching for Peptide Ligands with an Epitope Library,”Science 249:386-390, 1990.
Seed and Aruffo, “Molecular Cloning of the CD2 Antigen, the T-Cell Erythrocyte Receptor, by a Rapid Immunoselection Procedure,”Proc. Natl. Acad. Sci. USA 84:3365-3369, 1987.
Stoker and Rubin, “Density Dependent Inhibition of Cell Growth in Culture,”Nature 215:171-172, 1967.
Streuli et al., “A New Member of the Immunoglobulin Superfamily that has a Cytoplasmic Region Homologous to the Leukocyte Common Antigen,”J. Exp. Med. 168:1523-1530, 1988.
Streuli et al., “Expression of the Receptor-like Protein Tyrosine Phosphatase LAR: Proteolytic Cleavage and Shedding of CAM-Like Extracellular Region,”EMBO J. 11:897-907, 1992.
Sun et al., “MKP-1 (3CH134), an Immediate Early Gene Product, is a Dual Specificity Phophatase that Dephosphorylates MAP Kinase In Vivo,”Cell 75:487-493, 1993.
Tonks et al., “Purification of the Major Protein-Tyrosine Phosphatases of Human Placenta,”J. Biol. Chem. 263:6722-6730, 1988.
Tonks, “Protein Phosphatases: Key Players in the Regulation of Cell Function,”Curr. Opin. Cell. Biol. 2:1114-1124, 1990.
Vojtek et al., “Mammalian RAS Interacts directly with the Serine Threonine Kinase Raf,”Cell 74:205-214, 1993.
Wary et al., “A Homozygous Deletion Within the Carbonic Anhydrase-Like Domain of the Ptprg Gene in Murine L-Cells,”Cancer Res. 53:1498-1502, 1993.
Yang and Tonks, “Isolation of cDNA Clone Encoding a Human Protein-Tyrosine Phosphatase with Homology to the Cytoskeletal-Associated Proteins Band 4.1, Erzin, Talin,”Proc. Natl. Acad. Sci. USA 88:5949-5953, 1991.
Yang et al., “A Protein Kinase Substrate Identified by the Two-Hybrid System,”Science 257:680-682, 1992.
Yang et al., “Two Drosophila Receptor-like Tyrosine Phosphatase Genes are Expressed in a Subset of Developing Axons and Pioneer Neurons in the Embryonic CNS,”Cell 67:661-673, 1991.
Young and Davis, “Efficient Isolation of Genes by Using Antibody Probes,”Proc. Natl. Acad. Sci. USA 80:1194-1198, 1983.
Brady-Kalnay et al., “Homophilic Binding of a PTP.mu., a Receptor-Type Protein Phospharase, Can Mediate Cell-Cell Aggregation,”J. Cell Biol. 122:961-972, 1993.
Gebbink et al., “Cloning, Expression and Chromosomal Localization of a New Putative Receptor-Like Protein Tyrosine Phosphatase,”FEBS Lett. 290:123-130, 1991.
Hirsch et al., “Cloning and Expression of an Intron-less Gene for AKAP 75, an Anchor Protein for the Regulatory Subunit of cAMP-Dependent Protein Kinase II.bet

Affiliated with

Also associated with

Rating

Density enhanced protein tyrosine phosphatases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Density enhanced protein tyrosine phosphatases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Density enhanced protein tyrosine phosphatases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3746647