Dense star polymer conjugates as dyes

Details Dense star polymer conjugates as dyes Dense star polymer conjugates as dyes

1993-03-24

2001-11-06

Levy, Neil S. (Department: 1616)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

C106S031130, C106S031150, C106S004000, C424S001110, C424S001330, C424S001530, C424S009300, C424S078170, C424S401000, C424S405000, C424SDIG001, C521S025000, C521S028000, C523S105000, C525S417000, C528S363000

Reexamination Certificate

active

06312679

ABSTRACT:

FIELD OF THE INVENTION
The present invention concerns the use of dense star polymers as carriers for agricultural, pharmaceutical, and other materials.
BACKGROUND OF THE INVENTION
In recent years polymers referred to as dense star polymers or starburst polymers have been developed. It has been found that the size, shape and properties of these dense star polymers or starburst polymers can be molecularly tailored to meet specialized end uses. Starburst polymers have significant advantages which can provide a means for the delivery of high concentrations of carried material per unit of polymer, controlled delivery, targeted delivery and/or multiple species delivery or use.
SUMMARY OF THE INVENTION
In its broadest aspect, the present invention is directed to polymer conjugate materials comprising dense star polymers or starburst polymers associated with desired materials (hereinafter these polymer conjugates will frequently be referred to as “starburst conjugates” or “conjugates”), process for preparing these conjugates, compositions containing the conjugates, and methods of using the conjugates and compositions.
The conjugates of the present invention are suitable for use in a variety of applications where specific delivery is desired, and are particularly suited for the delivery of biologically active agents. In a preferred embodiment of the present invention, the starburst conjugates are comprised of one or more starburst polymers associated with one or more bioactive agents.
The starburst conjugates offer significant benefits over other carriers known in the art due to the advantageous properties of the starburst polymers. Starburst polymers exhibit molecular architecture characterized by regular dendritic branching with radial symmetry. These radially symmetrical molecules are referred to as possessing “starburst topology”. These polymers are made in a manner which can provide concentric dendritic tiers around an initiator core. The starburst topology is achieved by the ordered assembly of organic repeating units in concentric, dendritic tiers around an initiator core; this is accomplished by introducing multiplicity and selfreplication (within each tier) in a geometrically progressive fashion through a number of molecular generations. The resulting highly functionalized molecules have been termed “dendrimers” in deference to their branched (tree-like) structure as well as their oligomeric nature. Thus, the terms starburst oligomer and starburst dendrimer are encompassed within the term starburst polymer. Topological polymers, with size and shape controlled domains, are dendrimers that are covalently bridged through their reactive terminal groups, which are referred to as starburst “bridged dendrimers.” The term bridged dendrimer is also encompassed within the term “starburst polymer”.


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