Dengue virus peptides and methods

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 5, 435 71, 435 792, 435 794, 4351723, 435965, 435975, 4241861, 4242041, 4242181, 530324, 530328, G01N 3353, C12P 2100

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058245065

ABSTRACT:
Peptide antigens derived from the dengue virus type-2 glycoprotein NS1 are provided. The peptide antigens are specifically immunoreactive with sera from individuals infected with the dengue virus. The antigens are useful as diagnostic tools in determining whether an individual has been or is infected with dengue virus, and for discriminating between infection with dengue virus and infection with related flaviviruses. The antigens are also useful in vaccine compositions for immunizing individuals against infection with the dengue virus.

REFERENCES:
Blok et al., Arch. Virol. (1991) 118:209-223.
Blok et al., Virology, 187, 573-590 (1992).
Irie et al., Gene, 75 (1989) 197-211.
Aaskov, J.G., et al. "Serologically defined linear epitopes in the envelope protein of dengue 2 (Jamaica strain 1409)", Arch Virol 105:209-221 (1989).
Bauminger, S. & Wilchek, M. "The USe of Carbodiimides in the Preparation of Immunizing Conjugates" Methods in Enzymology 70:151-159 (1980).
Coulis, P.A., et al., "Peptide-based immunodiagnosis of retrovirus infections", Amer Clin Prod Review, Nov. 1987.
Deubel V., et al., "Nucleotide Sequence and Deduced Amino Acid Sequence of the Nonstructural Proteins of Denque Type 2 Virus, Jamaica Genotype, Comparative Analysis of the Full-Length Genome", Virology 165:234-244 (1988).
Falconar, A.K.I., et al., "Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1", J Gen Virol 72:961-965 (1991).
Fu, J., et al. "Full-Length cDNA Sequence of Dengue Type 1 Virus (Singapore Strain S275/90)", Virology 188:953-958 (1992).
Geysen, H.M., et al., "Strategies for epitode analysis using peptide synthesis", J Immun Methods 102:259-274 (1987).
Geysen, H.M., et al., "Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid", Proc Natl Acad Sci USA 81:3998-4002 (Jul. 1984).
Gnann Jr., J.W., et al., "Diagnosis of AIDS by Using a 12-Amino Acid Peptide Representing an Immunodominant Epitode of the Human Immunodeficiency Virus", J Infectious Disease 156(2):261-267 (Aug. 1987).
Heinz, F.X., "Epitope Mapping of Flavivirus Glycoproteins", Advances in Virus Research, 31:103-167 (1986).
Henchal, E.A., et al., "Topological Mapping of Unique Epitopes on the Dengue-2 Virus NS1 Protein Using Monoclonal Antibodies", J Gen Virol 68: 845-851 (1987).
Hoop, T.P., et al., "Prediction of protein antigenic determinants from amino acid sequences", Proc Natl Acad Sci USA, 78(6): 3824-3828 (Jun. 1981).
Innis, B.L., et al., "Identification of Continuous Epitopes of the Envelope Glycoprotein of Dengue Type 2 Virus", Am J Trop Med Hyg 40(6):676-687, (1989).
Mackow, E., et al., "The Nucleotide Sequence of Dengue Type 4 Virus: Analysis of Genes Coding for Nonstructural Proteins", Virology 159:217-228 (1987).
Mason, P.W., et al., "The antigenic structure of dengue type 1 virus envelope and NS1 proteins expressed in Escherichia coli", J Gen Virol 71:2107-2114 (1990).
Megret, F., et al., "Use of Recombinant Fusion Proteins and Monoclonal Antibodies to Define Linear and Discontinuous Antigenic Sites on the Dengue Virus Envelope Glycoprotein", Virology 187:480-491 (1992).
Osatomi, K. and Sumiyoshi, H., "Complete Nucelotide Sequence of Dengue Type 3 Virus Genome RNA", Virology 176:643-647 (1990).
Putnak, J.R., et al., "Functional and Antigenic Domains of the Dengue-2 Virus Nonstructural Glycoprotein NS-1", Virology 163:93-103 (1988).
Qu, X., et al., "Immunoreactivity and protective effects in mice of a recombinant dengue 2 Tonga virus NS1 protein produced in a baculovirus expression system", J Gen Virol 74:89-97 (1993).
Roehrig, J.T., et al., "Antibodies to Dengue 2 Virus E-Glycoprotein Synthetic Pepetides Identify Antigenic Conformation", Virology 177: 668-675 (1990).
Schlesinger, J.J., et al., "Protection of Mice Against Dengue 2 Virus Encephalitis by Immunization with the Dengue 2 Virus Non-structural Glycoprotein NS1", J Gen Virol 68:853-857 (1987).
Shirahama, H. and Suzawa, T. "Absorption of bovine serum albumin onto styrene/acrylic acid copolymer latex", Colloid & Polymer Sci 263:141-146 (1985).
Songergard-Andersen, J., et al., "Covalently linked peptides for enzyme-linked immunosorbent assay", J Imm Methods, 131:99-104 (1990).
"Report of a WHO workshop on synthetic peptides in HIV diagnosis and AIDS-related research, Moscow 24-26 May 1989", World Health Organization Report, AIDS, 5:WHO1-WHO9 (1991).
"Dengue haemorrhagic fever: diagnosis, treatment and control", Published by World Health Organization, ISBN 92 4 154209 8 (1986).
Young, P.R., "Antigenic Analysis of Dengue Virus Using Monoclonal Antibodies", Southeast Asian J Trop Med Public Health, 21(4) : 646-651 (1990).
Zhang, Y-M, et al., "Immunization of Mice with Dengue Structural Proteins and Nonstructural Protein NS1 Espresses by Baculovirus Recombinant Induces Resistance to Dengue Virus Encephalitis", J Virol 62(8):3024-3031 (1988).

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