Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2009-12-08
2011-11-29
Chen, Stacy B. (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C424S218100
Reexamination Certificate
active
08067566
ABSTRACT:
The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain.
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patent: WO-00/57907 (2000-10-01), None
patent: WO-02/095075 (2002-11-01), None
patent: WO-03/092592 (2003-11-01), None
Kinney et al, “Development of new vaccine against dengue fever and Japanese encephalitis”, 2001, pp. 176-197, vol. 44, Intervirology.
Kinney et al, “Construction of Infectious cDNA for Dengue 2 Virus: Strain 16681 and its attenuated Vaccine Derivative, Strain PDK-53”, Apr. 14, 1997, pp. 300-308, vol. 230, No. 2, Academic Press Orlando, Florida, USA.
Butrapet et al, “Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5′ noncoding region and nonstructural proteins 1 and 3”, Apr. 2000, pp. 3011-3019, vol. 74, No. 7, Journal of Virology, The American Society for Microbiology, USA.
Putnak et al, “Development of a purified, inactivated, dengue-2 virus vaccine prototype in vero cells: Immunogenicity and protection in mice and rhesus monkeys”, Dec. 1996, pp. 1176-1184, vol. 174, No. 6, Journal of Infectious Diseases, Chicago, IL, USA.
Montagnon et al, “Experience with vero cells at Pasteur merieux connaught developments in biological standardization”, 1997, pp. 137-140, vol. 98, Developments in Biological Standardization, Karger, Basel, CH.
Barban Véronique
Guy Bruno
Kinney Claire Y. H.
Kinney Richard
Lang Jean
Centers for Disease Control and Prevention
Chen Stacy B.
Sanofi Pasteur
Schulman, Esq. B. Aaron
Stites & Harbison PLLC
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