Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2007-08-28
2007-08-28
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001650
Reexamination Certificate
active
10327455
ABSTRACT:
The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have multiple functional groups at the polymer surface. In addition, they have heterofunctional groups on the poly(amino acid) side chains for drug or diagnostic agent attachment. They are designed to allow sufficient preservation of the binding affinity of the targeting ligand while conjugating therapeutic or diagnostic agents to the polymers. The present invention also describes methods of production of the polymer carriers and methods for the treatment or diagnosis of diseases employing the polymer carriers. The present invention also includes methods to introduce targeting moieties site-specifically to the end of polymer chains.
REFERENCES:
patent: 4418068 (1983-11-01), Jones
patent: 4507466 (1985-03-01), Tomalia et al.
patent: 4558120 (1985-12-01), Tomalia et al.
patent: 4568737 (1986-02-01), Tomalia et al.
patent: 4587329 (1986-05-01), Tomalia et al.
patent: 4631337 (1986-12-01), Tomalia et al.
patent: 4694064 (1987-09-01), Tomalia et al.
patent: 4713975 (1987-12-01), Tomalia et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4737550 (1988-04-01), Tomalia
patent: 4857599 (1989-08-01), Tomalia et al.
patent: 4871779 (1989-10-01), Killat et al.
patent: 4988496 (1991-01-01), Srinivasan et al.
patent: 5087616 (1992-02-01), Myers et al.
patent: 5108921 (1992-04-01), Low et al.
patent: 5164294 (1992-11-01), Skold et al.
patent: 5279811 (1994-01-01), Bergstein et al.
patent: 5412072 (1995-05-01), Sakurai et al.
patent: 5416016 (1995-05-01), Low et al.
patent: 5517993 (1996-05-01), Unger et al.
patent: 5534241 (1996-07-01), Torchilin et al.
patent: 5602112 (1997-02-01), Rubinfeld
patent: 5605671 (1997-02-01), Lyle et al.
patent: 5635382 (1997-06-01), Low et al.
patent: 5635603 (1997-06-01), Hansen et al.
patent: 5670132 (1997-09-01), Griffiths et al.
patent: 5688488 (1997-11-01), Low et al.
patent: 5730968 (1998-03-01), Butterfield et al.
patent: 5820847 (1998-10-01), Low et al.
patent: 5830431 (1998-11-01), Srinivasan et al.
patent: 5908777 (1999-06-01), Lee et al.
patent: 5951964 (1999-09-01), Dean et al.
patent: 5955053 (1999-09-01), Marzilli et al.
patent: 5977163 (1999-11-01), Li et al.
patent: 5986074 (1999-11-01), Marzilli et al.
patent: 6071533 (2000-06-01), Papahadjopoulos et al.
patent: 6083741 (2000-07-01), Hart et al.
patent: 6103487 (2000-08-01), Barnett et al.
patent: 6113946 (2000-09-01), Szoka, Jr. et al.
patent: 6197278 (2001-03-01), Blankenberg et al.
patent: 6251866 (2001-06-01), Prakash et al.
patent: 6262107 (2001-07-01), Li et al.
patent: 6733755 (2004-05-01), Tchistiakova et al.
patent: 2001/0034363 (2001-10-01), Li et al.
patent: 2001/0041189 (2001-11-01), Xu
patent: 0554708 (1993-01-01), None
patent: 0693073 (1994-03-01), None
patent: WO95/28966 (1995-11-01), None
patent: WO97/33552 (1997-09-01), None
patent: WO99/39748 (1999-08-01), None
patent: WO99/49901 (1999-10-01), None
patent: WO99/61512 (1999-12-01), None
patent: 00/02587 (2000-01-01), None
patent: WO 00/53233 (2000-09-01), None
patent: WO 00/61788 (2000-10-01), None
patent: WO 01/91807 (2001-12-01), None
patent: 02/077036 (2002-10-01), None
Higashi et al (Chem. Commun., 2000, 361-362).
International PCT Search Report PCT/US02/40937, 9 pages, Mailed Apr. 4, 2003.
Aoi, K., et al. “Globular Carbohydrate Macromolecule ‘Sugar Balls’ 3. ‘Radical-Growth Polymerization’ of Sugar-Substituted α-Amino AcidN-Carboxyanhydrides (GlycoNCAs) with a Dendritic Initiator”; Tetrahedron, Elsevier Science Publishers, Amsterdam, NL, vol. 53, No. 45; pp. 15415-15427, Nov. 10, 1997.
Hudecz, F., et al. “Influence of Carrier on Blodistribution and in Vitro Cytotoxicty of Methotrexate-Branched Polypeptide Conjugates”, Bioconjugate Chemistry, American Chemical Society; vol. 4, No. 1, pp. 25-33, Jan. 1993.
Pimm, M.V. et al. “Strategies for Labelling Branched Polypeptides with a Poly (L-Lysine) Backbone with Radioiodines123I,125I,131I) and Radiometals (111In,51Cr) for Biodistribution Studies and Rediopharmaceutical Development”, Journal of Labelled Compounds and Radiopharmaceuticals; vol. 36 No. 2, pp. 157-172, 1995.
Brokx, R., et al. “Designing peptide-based scaffolds as drug delivery vehicles”, Science Publishers B.V. Amsterdam, vol. 78 No. 1-3, pp. 115-123, Jan. 17, 2002.
Klok, H. et al. “Star-Shaped Fluorescent Polypeptides”, Journal of Polymer Science, vol. 39 No. 10, pp. 1572-1582, Feb. 20, 2001.
Gariepy, J. et al. “A Novel Method of Conjugation of Daunomycin with Antibody with a Poly-L-glutamic Acid Derivative as Intermediate Drug Carrier, An Anti-α-fetoprotein Antibody-Daunomycin Conjugate”, Journal of Medicinal Chemistry, vol. 27 No. 12, pp. 1602-1607, 1984.
Gariepy J. et al. “Vectorial delivery of macromolecules into cells using peptide-based vehicles”, Trends in Biotechnology, vol. 19 No. 1, pp. 21-28, Jan. 1, 2001.
PCT International Preliminary Examination Report for International Application No. PCT/US02/12502, 6 pages, Mailing Date Oct. 13, 2004.
PCT International Preliminary Examination Report for International Application No. PCT/US02/40937, 4 pages, Mailing Date Oct. 19, 2004.
PCT International Search Report PCT/US02/12502. 7 pages, Mailed Oct. 9, 2003.
Benns et al., “Tailoring new gene delivery designs for specific targets”. Journal of Drug Targeting, vol. 8, No. 1 Database Medline on STN International, Accession No. 2000222278. 2 pages, 2000.
Blair et al., “Linkage of Cytotoxic Agents to Immunoglobulins”. Journal of Immunological Methods, vol. 59, pp. 129-143, 1983.
Greenfield et al., “In Vitro Evaluation of Immunoconjugates Prepared by Linking Mitomycin C to Monoclonal Antibodies via Polyglutamic Acid Carriers”. Antibody, Immunoconjugates, and Radiopharmaceuticals. vol. 2, No. 3, pp. 201-216, 1989.
International PCT Search Report PCT/US02/12510, 6 pages, Mailed Sep. 12, 2003.
Anderson et al. “Radiometal-Labeled Agents(Non-Technetium)for Diagnostic Imaging” Chem. Rev. vol. 99 pp. 2219-2234, 1999.
Bajorin et al. Proceedings of the American Society of Clinical Oncology American Society of Clinical Oncology, Inc., vol. 7, p. 250, Mar. 1988.
Baselga et al. “Phase I Studies of Anti-Epidermal Growth Factor Receptor Chimeric Antibody C225 Alone and in Combination with Cisplatin” J Clinical Oncology vol. 18 pp. 904-914, 2000.
Baselga et al. “Recombinant Humanized Anti-HER2 Antibody(Herceptin)Enhances the Antitumor Activity of Paclitaxel and Doxorubicin Against HER2/New Overexpressing Human Breast Cancer Xenografts” Cancer Research vol. 58 pp. 2825-2831, 1998.
Blackenberg et al. “Apoptosis: The Importance of Nuclear Medicine” Nucl. Med. Comm. vol. 21 pp. 241-250, 2000.
Blackenberg et al. “In VivoDetection and Imaging of Phosphatidylserine Expression During Programmed Cell Death” Proc. Natl. Acad. Sci. USA vol. 95 pp. 6349-6354, 1998.
Blackenberg et al. “Imaging of Apoptosis(Programmed Cell Death)with TC Annexin V” J. Nuclear Medicine vol. 40 pp. 184-191, 1999.
Block et al. “Poly(g-benzyl-L-glutamate)and Other Glutamic Acid Containing Polymers” Gordon and Breach Science Publishers, NY p. 11-31, 1983.
Bohdiewicz et al. “Indium-111 Satumomab Pendetide: The First FDA-Approved Monoclonal Antibody for Tumor Imaging” J Nuclear Medicine Technology vol. 26 pp. 155-163, 1998.
Brechbiel et al. “Synthesis of 1(P-Isothiocyanatobenzyl)Derivatives of DTPA and EDTA. Antibody Labeling and Tumor-Imaging Studies” Inorg Chem. vol. 25 pp. 2772-2781, 1986.
Chapman et al. “Therapeutic Antibody Fragments Iwth Prolonged in vivo Half-Lives” Nature Biotech. vol. 17 pp. 780-783, 1999.
Collier et al. “Immunoscintlgraphy Performed with In-111-Labeled CYT-103 in the Management of Coloretal Cancer: Comparison with CT” Radiolo
Charnsangavej Chusilp
Li Chun
Tansey Wayne
Wallace Sidney
Baker & Botts L.L.P.
Board of Regents , The University of Texas System
Jones Dameron L.
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