Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2002-07-31
2008-10-28
Ewoldt, G. R. (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S355000
Reexamination Certificate
active
07442547
ABSTRACT:
The present invention is based on the discovery that in response to different stimuli, dendritic cells initiate various immune responses by producing different transcription profiles, e.g., IL-2 production by dendritic cells in response to a microbial stimulus. The present invention provides methods of making libraries of gene expression profiles and libraries made thereof corresponding to dendritic cell maturation in response to a microbial stimulation. The present invention provides methods for activating lymphocytes or immune responses and methods for producing Il-2 in dendritic cells or preparing dendritic cells for cell-based therapy. The present invention also provides methods and systems for screening agents affecting dendritic cell maturation. In addition, it is the discovery of the present invention that dendritic cells are targets for immunosuppressive virus infections. Accordingly, the present invention provides methods for treating immunosuppressive virus infections or immunosuppression associated with immunosuppressive virus infection. The present invention also provides methods for screening candidate therapeutic agents suitable for treating immunosuppressive virus infection using dendritic cell system.
REFERENCES:
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Granucci Francesca
Ricciardi-Castagnoli Paola
DLA Piper (LLP) US
Ewoldt G. R.
Juedes Amy
Sekmed, S.R.L.
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