Dendritic cell-derived growth factor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435455, 435325, 4352523, 43525411, 4353201, 536 231, 536 235, 536 2351, 536 241, 536 243, 536 2431, 536 2433, C12N 1516, C12N 121, C12N 510, C12N 1563

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059687800

ABSTRACT:
The present invention relates to a novel DCDGF protein which is a member of a novel family of growth factors of which the prototype is called Insect-Derived Growth Factor (IDGF). In particular, isolated nucleic acid molecules are provided encoding the human DCDGF protein. DCDGF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DCDGF activity. Also provided are diagnostic methods for diagnosing DiGeorge Syndrome and, particularly, immune system-related disorders. and therapeutic methods for treating immune system-related disorders.

REFERENCES:
Database Embl, Accession No. G10193, Aug. 17, 1995.
Database Embl, Accession No. U41528, Dec. 9, 1995.
Mohamadzadeh, M. et al., J. of Immun., 156 (9):3102-3106 (May 1, 1996).
Homma, K. et al., J. of Biol. Chem., 271:13770-13775 (1996).
Genbank Acc. No. AA081788 (Oct. 1996).
Genbank Acc. No. R50107 (May 1995).
Genbank Acc. No. R98295 (Sep. 1995).

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