Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2006-02-28
2006-02-28
Webman, Edward J. (Department: 1616)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
C424S078210, C424SDIG016
Reexamination Certificate
active
07005124
ABSTRACT:
Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to an antineoplastic agent capable of interacting with the functional groups, and contacting the dendritic polymer with the antineoplastic agent. The preferred platin-based analogues of the antineoplastic agents conjugated to the dendritic polymer may be administered intravenously, orally, parentally, subcutaneously, intramuscularly, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, reduced toxicity, and improved anti-tumor activity in vivo.
REFERENCES:
Esfand, et al., “Poly(amidoamine) (PAMAM) Dendrimers: from Biomimicry to Drug Delivery and Biomedical Applications”, DDT vol. 6, No. 8, pp. 427-436 (Apr. 2001).
Malik, et al., “Dendrimer-Platinate: A Novel Approach to Cancer Chemotherapy”, Anti-Cancer Drugs, 10, pp. 767-776 (1999).
Ohndorf, et al., “Basis for Recognition of Cisplatin-Modified DNA by High-Mobility-Group Proteins”, Letters to Nature, vol. 299, pp. 708-712, (Jun. 1999).
Duncan Ruth
Esfand Roseita
Malik Navid
Tomalia Donald A.
Dendritic Nanotechnologies Inc.
Kimble Karen L.
Webman Edward J.
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