Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2011-01-04
2011-01-04
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
Reexamination Certificate
active
07862807
ABSTRACT:
Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.
REFERENCES:
patent: 4694064 (1987-09-01), Tomalia et al.
patent: 4857599 (1989-08-01), Tomalia et al.
patent: 5387617 (1995-02-01), Hedstrand et al.
patent: 6020457 (2000-02-01), Klimash et al.
patent: 6177414 (2001-01-01), Tomalia et al.
patent: 6190650 (2001-02-01), Matthews et al.
patent: 6306993 (2001-10-01), Rothbard et al.
patent: 6395867 (2002-05-01), Maignan
patent: 6485718 (2002-11-01), Parthasarathy et al.
patent: WO 91/09958 (1991-07-01), None
patent: WO 94/04686 (1994-03-01), None
patent: WO 98/52614 (1998-11-01), None
Kasai et al 12 Bioorganic & Medicinal Chemistry Letters 951 (Mar. 25, 2002).
Liu et al 2 Pharmaceutical Sciences & Technology Today 393 (Oct. 1, 1999).
Buschle, M. et al., Transloading of tumor antigen-derived peptides into antigen-presenting cells. Proc. Natl. Acad. Sci. USA., 94, p. 3256-3261 (1997).
Emi, N. et al., Gene Transfer Mediated by Polyarginine Requires a Formation of Big Carrier-Complex of DNA Aggregate, Biophys. Res. Commun., 231, p. 421-424 (1997).
Feichtinger, L. et al., Triurethane-Protected Guanidines and Triflydiurethane-Protected Guanidines: New Reagents for Guanidinylation Reactions, J. Org. Chem., 63, p. 8432 (1998).
Leonetti, J. -P. et al., Biological Activity of Oligonucleotide-Poly(L -lysine) Conjugates: Mechanism of Cell Uptake, Bioconjugate Chem., 1, p. 149-153 (1990).
Mitchell, D.J. et al., Polyargine enters cells more efficiently than other polycationic homopolymers, J. Peptide Res., 55 p. 318-325 (2000).
Murphy, J.E. et al., A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery, Proc. Natl. Acad. Sci. USA., 95, p. 1517-1522 (1998).
Pepinsky, R.B. et al., Specific Inhibition of a Human Papillomavirus E2Trans-Activator by Intracellular Delivery of Its Repressor, DNA Cell Biol., 13, p. 1011-1019 (1994).
Ryser, H.J.-P., A Membrane Effect of Basic Polymers dependent on Molecular Size, Nature (London), 215, p. 934-936 (1967).
Ryser, N. J. -P. et al., Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells, Proc. Nat. Acad. Sci. USA., 75, p. 3867-3870 (1978).
Schwarze, S.R. et al., In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse, Science, 285, p. 1569-1572 (1999).
Shen, W., et al., Conjugation of poly-L-lysine to albumin and horseradish peroxides:. A novel method of enhancing the cellular uptake of proteins, Proc. Nat. Acad. Sci. USA., 75, p. 1872-1876 (1978).
Vocero-Akbani, A.M. et al., Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein, Nat. Med., 5, p. 29-33 (1999).
Wender, P.A. et al., The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters, Proc. Natl. Acad. Sci. USA., 97, p. 13003-13008 (2000).
Supplementary European Search Report, pp. 6, Jul. 26, 2007.
Mitchell, D. J. et al., “Polyarginine Enters Cells More Efficiently Than Other Polycationic Homopolymers”, Journal of Peptide Research, vol. 56, No. 5, pp. 318-325, Nov. 2000 (2000-11), Abstract.
Ranganathan, D. et al., “Design and Synthesis of AB3-Type (A=1, 3, 5-Benzenetricarbonyl Unit”,Biopolymers, vol. 54, No. 4, pp. 289-295, 2000, Abstract.
Rothbard, J. B. et al., “Conjugation of Arginine Oligomers to Cyclosporin a facilitates Topical Delivery and Inhibition of Inflammation”,Nature Medicine, vol. 6, No. 11, pp. 1253-1257, Nov. 2000 (2000-11), Abstract.
Scott, D. A. et al, “Bis(1, 3-dihydroxy-isopropyl)amine (BDI) as an AB4 Dendritic Building Block: Rapid Synthesis of a Second Generation Dendrimer”, Tetrahedron Letters, vol. 41, No. 20, pp. 3959-3962, May 2000 (2000-05), Abstract.
Futaki et al., Translocation of Branched-Chain Arginine Peptides through Cell Membranes: Flexibility in the Spatial Disposition of Positive Charges in Membrane-Permeable Peptides, Biochemistry, 41: 7925-7930, (2002).
International Search Report dated Apr. 16, 2004 for PCT Application No. PCT/US03/22772.
International Search Report dated Apr. 23, 2004 for PCT Application No. PCT/US03/22771.
Goodman Murray
Harms Guido
Seong Churl Min
Dickinson Paul
Foley & Lardner LLP
Hartley Michael G
Reiter Stephen E.
University of California San Diego
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