Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1995-05-30
1998-08-04
Schofer, Joseph L.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424 7817, 424DIG16, A61K 914, A61K 4748
Patent
active
057889899
ABSTRACT:
The invention relates to a dendrimer composition in which an effective number of the terminal functionalities are provided with blocking agents, and at least one active substance species is occluded in the dendrimer. A blocking agent is a sufficiently sterically sized compound which readily enters into a chemical bond with a terminal group of a dendrimer but which can also be split off from the dendrimer or can be modified without affecting the chemical structure of the dendrimer and the occluded active substance. The blocking agent can also be provided with a protecting group. The time and duration over which an active substance is released can be controlled. The invention also relates to a process for the preparation of such a composition and to a process for the controlled release of the active substance.
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de Brabander-van den Berg Ellen M. M.
Jansen Johan F. G. A.
Meijer Egbert W.
Cheng Wu C.
DSM N.V.
Schofer Joseph L.
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