Denatured albumin complexes for radioscintigraphic imaging and e

Details Denatured albumin complexes for radioscintigraphic imaging and e Denatured albumin complexes for radioscintigraphic imaging and e

1979-03-07

1982-06-29

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260112R, 260122, 424 15, 424 9, A61K 4900, A61K 4300, C07G 700

Patent

active

043372406

ABSTRACT:
Small sized material (less than 0.2 .mu.m, preferably less than 0.1 .mu.m) comprising a complex of (1) denatured albumin, particularly human serum albumin and (2) a metal reducing agent, particularly a stannous reducing agent, preferably formed in the presence of a stabilizing ligand, which complex, when labelled with technetium-99m provides an excellent agent for imaging or otherwise evaluating reticuloendothelial systems (RES) and/or components thereof, particularly the bone marrow, liver and/or lymphatic system; methods of making and using the same; a complex (physical or chemical) of technetium-99m with such materials and methods of using such latter complex.

REFERENCES:
patent: 3720761 (1973-03-01), Hunter
patent: 3863004 (1975-01-01), Wolfangel
patent: 4032625 (1977-06-01), Sobrramanian et al.
patent: 4071613 (1978-01-01), Hunter
patent: 4094965 (1978-06-01), Layne et al.
Un et al., J. Nucl. Med., 13 (1972), 58-65; 928-931.
Honda et al., J. Nucl. Med., vol. 11, No. 10, 1970, pp. 580-585.
McCutcheons Detergents and Emulsifiers, North American Edition, (1973), pp. 213-217.
Wagner et al., J. Clin. Inv., 42:417 (1963).

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