Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se – Higher plant – seedling – plant seed – or plant part
Reexamination Certificate
2007-08-07
2007-08-07
Collins, Cynthia (Department: 1638)
Multicellular living organisms and unmodified parts thereof and
Plant, seedling, plant seed, or plant part, per se
Higher plant, seedling, plant seed, or plant part
C435S320100, C435S252300, C435S254200, C435S419000, C435S348000
Reexamination Certificate
active
10233409
ABSTRACT:
Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.
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Lee et al. “Structure and In Vitro Molecular Chaperone Activity of Cytosolic Small Heat Shock Proteins From Pea”, Journal of Biological Chemistry, 270(18): 10432-10438, 1995.
Basler et al. “Hamster (Syrian Golden) PrP Gene, Complete Cds: Scrapie and Cellular PrP Isoforms Are Encoded by the Same Chromosomal Gene”, GenBank Accession No. 14054, 1993.
Prusiner et al. “Prion Protein Biology”, Cell, 93: 337-348, 1998.
Liautard “Prions and Molecular Chaperones”, Arch. Vir., 7(Suppl.): 227-243, 1993.
Sun et al. “Conformational and Functional Differences Between Recombinant Human Lens αA- and αB-Crystallin”, Journal of Biological Chemistry, 272(10): 6220-6225, 1997.
Sun et al. “Thermodynamic Stability of Human Lens Recombinant αA- and αB-Crystallins”, Journal of Biological Chemistry, 274(48): 34067-34071, 1999.
Broun et al. “Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids”, Science, 282: 1315-1317, 1998.
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Alegrand Tal
Altman Arie
Marton Ira
Pelah Dan
Pouny Yehonathan
Collins Cynthia
Fulcrum SP Ltd.
Yissum Research Development Company of the Hebrew University of
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