Demycinosyltylosin and process for its production

Details Demycinosyltylosin and process for its production Demycinosyltylosin and process for its production

1980-06-12

1982-03-23

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 435 76, A61K 3171, C07H 1708

Patent

active

043213618

ABSTRACT:
23-Demycinosyltylosin (DMT) which has the formula: ##STR1## 20-dihydro-DMT, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents. Improved methods of making 5-O-mycaminosyltylonolide (OMT) and 20-dihydro-OMT by mild acid hydrolysis of DMT and 20-dihydro-DMT, respectively, are included.

REFERENCES:
patent: 3178341 (1965-04-01), Hamill et al.
patent: 3326759 (1967-06-01), Hamill et al.
patent: 3344024 (1967-09-01), Whaley et al.
patent: 3459853 (1969-08-01), Gorman et al.
patent: 3923784 (1975-12-01), Kierstead et al.
patent: 3939144 (1976-02-01), Radobolja et al.
patent: 4056616 (1977-11-01), Reimann et al.
patent: 4161523 (1974-10-01), Weinstein et al.
patent: 4196280 (1980-04-01), Umezawa et al.
patent: 4205163 (1980-05-01), Mori et al.
A. Kinumaki et al. "J. Antibiotics", vol. 30, No. 6, pp. 450-454, 1977.
Tanabe Pharmaceuticals, Japanese Examined Pat. No. 6037-351 (Derwent Abstract 86252x/46 only).
Yamaguchi et al., "J. Antibiotics", vol. 31, No. 5, pp. 433-440, 1978.
Tanabe Pharmaceuticals, Japanese Examined Pat. No. 6037-352 (Derwent Abstract 86253x/46 only).
Tsukiura et al. "J. Antibiotics", vol. 22, No. 3, pp. 89-99, 1969.
Suzuki et al., "Chem. Letters", 1973, pp. 793-798.
Nash et al., "Current Chemotherapy & Infectious Diseases Proc. of 11th ICC & 19th ICAAC., Amer. Soc. of Microbiology, pp. 462-463, 1980.
Nagel et al., "J. Org. Chemistry", 44 No. 12, pp. 2050-2052, 1979.
Masamune et al., "J. Amer. Chem. Soc.", 98 #24, pp. 7874-7875, 1976.
Okamoto et al., "Japanese Kokai Tokyo Koho" 80; 43,0183 (abstract from Chem. Abst. vol. 93, 68663u (1980) only).

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