Demethylation of 14-hydroxy substituted alkaloid derivatives

Details Demethylation of 14-hydroxy substituted alkaloid derivatives Demethylation of 14-hydroxy substituted alkaloid derivatives

2008-10-29

2009-11-17

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S014000, C546S044000

Reexamination Certificate

active

07619088

ABSTRACT:
The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N═N—COOR2in a suitable solvent.

REFERENCES:
patent: 4141897 (1979-02-01), Olofson et al.
patent: 1124441 (1968-08-01), None
patent: 2006/084389 (2006-08-01), None
XP-002428747: Iijima, I., et al.,“Studies in the (+)-Morphinan Series. V. Synthesis and Biological Properties of (+)-Naloxone”,Journal Of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 21, No. 4, pp. 398-400, (1978).

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