Demethyl maytansinoids

Details Demethyl maytansinoids Demethyl maytansinoids

1980-05-27

1981-12-22

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424854, 435119, C07D49816, C07D49818

Patent

active

043070167

ABSTRACT:
Novel demethylmaytansinoids representable by the formula: ##STR1## [wherein X is Cl or H; R.sub.1 is H or acyl group] are produced from maytansinoids by means of enzymic transformation. The demethylmaytansinoids are useful as antifungal, antiprotozoal or antitumor agents.

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4162490 (1979-07-01), Higashide et al.
Kupchan et al. "J. Med. Chem." vol. 21, No. 1, pp. 31-37 (1978).

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