Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-11-08
2005-11-08
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S265000
Reexamination Certificate
active
06962921
ABSTRACT:
Medicines for treatment or prevention of dementia comprising 2-aryl-8-oxodihydropurine derivatives of the formula (I):wherein W is H, C1-6alkyl, halogen, C1-6alkoxy, or the like; X is H, C1-6alkyl, a group of the formula (Q): —CH(R3)CON(R1) (R2) (wherein R1is a C1-6alkyl or the like; R2is phenyl-substituted C1-4alkyl or the like; and R3is H or the like); Y is H, C1-6alkyl, a group of the above formula (Q), or the like; and A is substituted phenyl or the like, with the proviso that one of X and Y is a group of the formula (Q) and the other is a group selected from those defined for X or Y except the groups (Q), or pharmaceutically acceptable acid addition salts thereof. The above compounds exhibit an extremely potent ameliorating effect on learning disorder and/or dymnesia and thus are useful in the treatment or prevention of Alzheimer-type dementia, cerebrovascular dementia, senile dementia, etc.
REFERENCES:
patent: 5380739 (1995-01-01), Clark et al.
patent: 5453428 (1995-09-01), Kaminski
patent: 5470868 (1995-11-01), Young
patent: 6372740 (2002-04-01), Murata et al.
patent: 0 882 727 (1998-12-01), None
patent: 2001048882 (2001-02-01), None
patent: 99/28320 (1999-06-01), None
“A Depression Symptoms Checklist”, <http://www.pueblo.gsa.gov/cic_text/health/over-65/symptoms.htm> downloaded from the Internet Nov. 23, 2004.
“Epilepsy and memory” <http://www.epilepsy.com/epilepsy/memory.html> downloaded from the Internet Nov. 23, 2004.
Munoz, CMAJ 2000;162:65-72.
Palmer TRENDS in Pharmacological Sciences 23(9) 426-433 Sep. 2002.
E. Romeo et al., “Mitochondrial Diazepam-Binding Inhibitor Receptor Complex Agonists Antagonize Dizocilpine Amnesia: Putative Role for Allopregnanolone”, The Journal of Pharmacology and Experimental Therapeutics, vol. 270, No. 1, pp. 89 to 96, 1994.
Patent Abstracts of Japan, Abstract of JP 2001-048882, Published Feb. 20, 2001.
James F. Flood et al., “Dehydroepiandrosterone Sulfate Improves Memory in Aging Mice”, Brain Research, vol. 448, pp. 178-181, 1988.
James F. Flood et al., “Memory-enhancing Effects in Male Mice of Pregnenolone and Steroids Metrobolically Derived from it”, Proc. Natl. Acad. Sci., vol. 89, pp. 1567-1571, Mar. 1992.
E. Romeo et al., “2-Aryl-3-Indoleacetamides (FGIN-1): A New Class of Potent and Specific Ligands for the Mitochondrial DBI Receptor (MDR)”, The Journal of Pharmacology and Experimental Therapeutics, vol. 262, No. 3, pp. 971-978, 1992.
Dennis J. Selkoe, “Biochemistry of Altered Brain Proteins in Alzheimer's Disease”, Ann. Rev. Neurosci, vol. 12, pp. 463-490, 1989.
C.G. Gottfries, “Alzheimer's Disease and Senile Dementia; Biochemical Characteristics and Aspects of Treatment”, Psychopharmacology, vol. 86, pp. 245-252, 1985.
Joseph T. Coyle et al., “Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation”, Science, vol. 219, pp. 1184-1190, 1983.
Spravochnik-poutivoditel praktikouyuschego vracha, 2000 diseases from A to Z, Moscow, GEORAR Meditgsina, pp. 288-289 and translation.
Furukawa Kiyoshi
Hashimoto Takashi
Kurumiya Satoshi
Berch Mark L.
Dainippon Pharmaceutical Co., Ltd.
Wenderoth , Lind & Ponack, L.L.P.
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