Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1997-06-04
1999-01-05
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
536 231, 536 232, 536 236, 4351721, 4351723, 435410, 435412, 435416, 435417, 435418, 435419, 435 691, 4353201, 800205, C12N 902, C07N 2104
Patent
active
058561579
ABSTRACT:
Isolation and characterization of a novel plant fatty acid desaturase cDNA that encodes a .DELTA..sup.9 14:0-ACP desaturase. Expression of the .DELTA..sup.9 14:0-ACP desaturase is a critical factor for pest resistance in plants of the genus Pelargonium and other plants generally; the desaturase gene is also useful in other contexts and for other purposes such as increasing the percentage of unsaturated fatty acids in oil-producing crops such as soybeans, rapeseed, maize, sunflower, safflower, cotton, cuphea, peanut, coconut and oil-palm, as well as increasing the percentage of unsaturated fatty acids in other plants generally.
REFERENCES:
David J. Schultz et al., "Expression of a .increment..sup.9 14:0-acyl carrier protein fatty acid desaturase gene is necessary for the production of .omega..sup.5 anacardic acids found in pest-resistant geranium (Pelargonium xhortorum)," Proc. Natl. Acad. Sci. USA, vol. 93, pp. 8771-8775, Aug. 1996, Plant Biology.
Edgar B. Cahoon et al., "Characterization of a structurally and functionally diverged acyl-acyl carrier protein desaturase from milkweed seed," Plant Molecular Biology, vol. 33, pp. 1105-1110, 1997.
Cahoon, Edgar B., et al., "Expression of a coriander desaturase results in petroselinic acid production in transgenic tobacco," Proc. Natl. Acad. Sci. USA, vol. 89, pp. 11184-11188, Dec. 1992, Plant Biology.
Cahoon, Edgar B. et al., ".increment..sup.6 Hexadecenoic Acid Is Synthesized by the Activity of a Soluble .increment..sup.6 Palmitoyl-Acyl Carrier Protein Desaturase in Thunbergia alata Endosperm," The Journal of Biological Chemistry, vol. 269, No. 44, Nov. 4, 1994, pp. 27519-27526.
Cahoon, Edgar B. et al., "Metabolic Evidence for the Involvement of a .increment..sup.4 -Palmitoyl-Acyl Carrier Protein Desaturase in Petroselinic Acid Synthesis in Coriander Endosperm and Transgenic Tobacco Cells," Plant Physiol., (1994) vol. 104, pp. 827-837.
Cahoon, Edgar B. et al., "Modification of the Fatty Acid Composition of Escherichia coli by Coexpression of a Plant Acyl-Acyl Carrier Protein Desaturase and Ferredoxin," Journal of Bacteriology, Feb. 1996, vol. 178, No. 3, pp. 936-939.
Cahoon, Edgar B. et al., "Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position," Proc. Natl. Acad. Sci. USA, vol. 94, pp. 4872-4877, May 1997, Biochemistry.
Cox-Foster Diana L.
Craig Richard
Medford June I.
Mumma Ralph O.
Schultz David
Monahan Thomas J.
Nashed Nashaat T.
Prouty Rebecca E.
The Penn State Research Foundation
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