Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-09-12
1991-05-28
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549264, A61K 31365, C07D31300
Patent
active
050195891
ABSTRACT:
The present invention relates to novel derivatives of LL-F28249 compounds wherein the 23-hydroxy group is eliminated to introduce a double bond at the 23,24 position. These resulting derivatives are .DELTA..sup.23 -LL-F28249 compounds. These LL-F28249 precursor compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subsp. noncyanogenus having deposit accession number NRRL 15773. The novel derivatives of the present invention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents. They also are useful in areas of human and animal health and in agricultural crops.
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patent: 4328335 (1982-05-01), Mrozik
patent: 4587247 (1986-05-01), Linn et al.
Burgess et al., J. Org. Chem., vol. 38(1), pp. 26-31, 1973.
Michael J. Green et al., Jour. Chem. Soc., Chem. Comm. (1977), pp. 611-612.
Lila Somekh et al., J. Org. Chem., vol. 48 (6), (1983), pp. 907-908.
Ahmed Zareen
Asato Goro
American Cyanamid Company
Ivy C. Warren
Trinh Ba K.
Tsevdos Estelle J.
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