.DELTA..sup.22 -derivatives of LL-F28249 compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549264, A61K 31365

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active

048868280

ABSTRACT:
The present invention relates to novel derivatives of LL-F28249 compounds. These LL-F28249 compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subsp. non-cyanogenus having deposit accession numer NRRL 15773. The derivatives of the present invention have the 23-hydroxy group react to form a double bond in the 22,23 position. The novel derivatives of the present invention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents. They also are useful in areas of human and animal health and in agricultural crops.

REFERENCES:
patent: Re32034 (1985-11-01), Chabala et al.
patent: 4328335 (1982-05-01), Mrozik
patent: 4378353 (1983-03-01), Goegelman et al.

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