.DELTA..sup.2,3 -1,4-MORPHOLINE-2-CARBOXYLIC ACIDS AND DERIVATIV

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D26500, C07D27300, C07D29500

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active

040123839

ABSTRACT:
There is described novel substituted .DELTA..sup.2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Q is hydrogen or alkyl and X is amino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are useful as intermediates in the preparation of antibacterial agents.

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