.DELTA..sup.2,3 -0-2-Isocephem-4-carboxylic acid and derivatives

Details .DELTA..sup.2,3 -0-2-Isocephem-4-carboxylic acid and derivatives .DELTA..sup.2,3 -0-2-Isocephem-4-carboxylic acid and derivatives

1975-07-23

1977-03-22

Meyers, Albert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424851, 42424852, C07D26500, C07D27300, C07D29500, A01N 900

Patent

active

040136485

ABSTRACT:
There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is amino and Z represents an optionally substituted heterocyclic ring containing N, O or S. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such anti-bacterial agents.

Affiliated with

Also associated with

Rating

.DELTA..sup.2,3 -0-2-Isocephem-4-carboxylic acid and derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .DELTA..sup.2,3 -0-2-Isocephem-4-carboxylic acid and derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .DELTA..sup.2,3 -0-2-Isocephem-4-carboxylic acid and derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1956011