.DELTA..sup.1 -Pyrroline thiolactim ethers and a process for the

Details .DELTA..sup.1 -Pyrroline thiolactim ethers and a process for the .DELTA..sup.1 -Pyrroline thiolactim ethers and a process for the

1982-05-05

1985-10-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514424, 548517, 548527, 548551, C07D20724, C07D40506, C07D40906, A61K 3140

Patent

active

045489360

ABSTRACT:
The present invention relates to .DELTA..sup.1 -pyrroline thiolactim ethers of the general formula I ##STR1## which have a more specific action and/or a longer-lasting action than PGI.sub.2, and to a process for their preparation.
The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.

REFERENCES:
patent: 4371542 (1983-02-01), Beck et al.
Burger ed., Medicinal Chemistry, 2nd ed., Interscience Pub., (1960), p. 42.
Chem. Abstracts 97: 198060p (1982).
Tetrahedron Letters 23, 2947-2950, (1982).

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