Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-01-06
1981-06-09
Love, Ethel G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602395, 26023955C, 2603975, 424241, A61K 3158, A61K 3156, C07J 100, C07J 300
Patent
active
042725305
ABSTRACT:
Novel 11.beta. -substituted-.DELTA. .sup.1,3,5(10) -estratrienes of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms and heterocycle with at least one sulfur or oxygen heteroatom, R.sub.2 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and aralkyl of 7 to 9 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, hydroxy, acyl of an organic carboxylic acid of 1 to 18 carbon atoms and acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms and R.sub.4 is selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 8 carbon atoms, acyloxy of an organic carboxylic acid of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms, with the proviso that R.sub.1 is not allyl when Z is hydrogen, R.sub.2 is methyl, R.sub.3 is hydroxy and R.sub.4 is hydrogen having estrogenic activity and their preparation.
REFERENCES:
patent: 3377365 (1968-04-01), Baran
patent: 3465010 (1969-09-01), Baran
patent: 3755301 (1973-08-01), Baran et al.
patent: 3922292 (1975-11-01), Torelli et al.
patent: 3927046 (1975-12-01), Van den Broek
patent: 3983144 (1976-09-01), Leemhuis
Fried, Organic Reactions in Steroid Chemistry, vol. 1, p. 314 (1972).
Philibert Daniel
Teutsch Jean G.
Love Ethel G.
Roussel Uclaf
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