Delta opioid receptor antagonists

Details Delta opioid receptor antagonists Delta opioid receptor antagonists

1987-07-29

1989-03-28

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544339, 544341, 546 31, 546 34, C07D48900, C07D48906

Patent

active

048165867

ABSTRACT:
Delta-opioid receptor antagonists are disclosed of the formula: ##STR1## wherein R.sup.1 is (C.sub.1 -C.sub.5)alkyl, C.sub.3 -C.sub.6 (cycloalkyl)alkyl, C.sub.5 -C.sub.7 (cycloalkenyl)alkyl, aryl, aralkyl, trans-(C.sub.4 -C.sub.5)alkenyl, allyl or furan-2-ylalkyl, R.sup.2 is H, OH or O.sub.2 CR, wherein R is (C.sub.1 -C.sub.5)alkyl; R.sup.3 is H, (C.sub.1 -C.sub.5)alkyl or RCO; X is O, S or NY, wherein Y is H or (C.sub.1 -C.sub.5)alkyl; M is N or CH; and R.sup.4 and R.sup.5 are individually H, F, Cl, Br, NO.sub.2, NH.sub.2, (C.sub.1 -C.sub.5)alkyl or (C.sub.1 -C.sub.5)alkoxy or R.sup.4 and R.sup.5 together are benzo; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4649200 (1987-03-01), Portoghese et al.
Y. Sawa et al., Chem. Abstracts, 73, 398, 120798v (1970).
C. F. C. Smith et al., Life Sci., 40, 267 (1987).

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