.delta. opioid receptor antagonists

Details .delta. opioid receptor antagonists .delta. opioid receptor antagonists

1994-01-04

1997-02-11

Lukton, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 514 17, 530328, 530329, 530330, A61K 3807

Patent

active

056020996

ABSTRACT:
The invention concerns compounds of the formula 1 ##STR1## and pharmaceutical compositions containing the compounds as active ingredients. The peptides of the invention are .delta. opioid receptor antagonists and are useful as analgesics and immunosuppressants.

REFERENCES:
Schiller, et al., in Peptides: Chemistry, Structure and Biology, Hodges and Smith, Eds., ESCOM, Leiden, pp. 483-486 (1994).
Schiller, et al., J. Med. Chem. 35, pp. 3956-3961 (1992).
Schiller, et al., J. Med. Chem. 36, pp. 3182-3187 (1993).
Schiller, et al. (1992) "Differential stereochemical requirements of mu vs delta opioid receptors . . . " Proceedings of the National Academy of Sciences, U.S.A. 89:11871.
Schiller, et al. (1992) Chemical Abstracts, 117:19235p "Conformationally restricted deltorphin analogs . .. ".
Portoghese, et al., (1988) "Application of the message . . . " 31: 281-282.
Portoghese, et al. (1991) "An approach to the design of receptor-type-selective non-peptide antagonists . . . " 34:1757-762.
Cotton, et al. (1984) "ICI 174864: a highly selective antagonist . . . " 97:331-332.
Schiller, et al. (1992) "A new class of potent and highly selective . . . " Abstract in FASEB J. 6:A1575.
Hermanson, Immobilized Affinity Ligand Techniques, 137-141 & 146, (1992).

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