.DELTA.Nur77 transgenic mouse

Details .DELTA.Nur77 transgenic mouse .DELTA.Nur77 transgenic mouse

1997-05-06

1999-11-09

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 11, 800 21, 800 22, 800 25, 800 3, 435455, 536 231, C12N 500, C12N 1500, C12N 1509, C12N 1563

Patent

active

059818298

ABSTRACT:
The present invention provides a transgenic mouse containing a transgene, said transgene comprising a truncated Nur77 (.DELTA.Nur77) gene. Also provided is a double transgenic mouse, wherein said double transgenic mouse comprises the .DELTA.Nur77 transgenic mouse backcrossed with the D.sup.b /HY T cell receptor transgenic mouse.

REFERENCES:
Augee et al. Platypus and Echidnas. The Royal Zoological Society of New South Wales, New South Wales, 1992.
Zhou et al. J. Experimental Medicine, Apr. 1, vol. 183, 1879-92, 1996.
Calnan et al. Immunity, Sep, vol. 3, 273-82, 1995.
Rothe et al. International Immunol., vol. 5, 11-17, 1993.
Kisielow et al. Nature, vol. 333, 742-745, 1988.
Mountz et al. J. Experimental Medicine, vol. 172, 1805-17, 1990.

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