Delta-like gene expressed in neuroendocrine tumors

Details Delta-like gene expressed in neuroendocrine tumors Delta-like gene expressed in neuroendocrine tumors

1996-02-01

1996-12-03

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435 912, 4351723, 436501, 436 63, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168, C07H 2100

Patent

active

055807380

ABSTRACT:
A polynucleotide molecule dlk is expressed in neuroendocrine tumors, including small cell lung carcinoma. A Dlk polypeptide encoded by dlk polynucleotide molecule can be used in detecting the existence of a primary or secondary neuroendocrine tumor. Monoclonal antibodies are produced against Dlk which are useful for detection and therapy of a neuroendocrine tumor.

REFERENCES:
Lee et al., Biochimica Et Biophysica Acta 1261: 223-232 (1995).
Mark J. Cooper et al, "Human Neuroblastoma Tumor Cell Lines Correspond to the Arrested Diffrentiation of Chromaffin Adrenal Medullary Neuroblasts," Cell Growth & Differentiation, 1989, pp. 149-159.
Lee J. Helman et al, "Molecular Markers of Neuroendocrine Development and Evidence of Environmental Regulation," Proc. Natl. Acad. Sci. USA, vol. 84, pp. 2336-2339, Apr. 1987.
Lee J. Helman et al, "The Sequence of an Adrenal Specific Human cDNA," pG2, Nucleic acids research, vol. 18, No. 3, p. 685.
LaBorda et al. (1993) The Journal of Biological Chemistry, vol. 268, No. 6, pp. 3817-3820.
Smas et al. (1993) Cell, vol. 73, pp. 725-734.

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