Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-04-04
1996-09-24
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514620, 544 581, 544168, 544316, 546216, 546226, 546233, 546237, 548131, 548187, 548204, 548232, 548253, 5483195, 5483381, 548546, 548550, 554 36, 554 37, 554 42, 554 45, A61K 31165, A61K 3154, C07D23720, C07D29414
Patent
active
055591116
ABSTRACT:
.delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
REFERENCES:
Plummer, M. et al, "Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(-P3)-P1 `sites`" Biorganic and Medicinal Chemistry Letters, 3 (10):2119-2124 (1993).
Hanessian, S. et al, "Design and Synthesis of a prototypical non-peptide inhibitor model for the enzyme Renin" Bioorg. and Medicinal Chemistry Letters, 4(14), 1696-1702 (1994).
Cohen Nissim C.
G oschke Richard
Herold Peter
Maibaum J urgen K.
Rigollier Pascal
Ciba-Geigy Corporation
Fishman Irving M.
Kaiser Karen G.
Mathias Marla J.
Ramsuer Robert W.
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