.DELTA.5-androstenes useful for promoting weight maintenance or

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

552636, A61K 3158, A61K 3156

Patent

active

054244633

ABSTRACT:
A method for promoting weight control by treating a subject with a therapeutic amount of one of the .DELTA.5-androstenes listed below to stimulate weight control without affecting appetite or inducing the synthesis of sex hormones. .DELTA.5-Androstenes providing the desired biological activities include:

REFERENCES:
patent: 4511511 (1985-04-01), Lewbart
patent: 4518595 (1985-05-01), Coleman et al.
patent: 4897390 (1990-01-01), Ruhe
patent: 4898694 (1990-02-01), Schwartz et al.
patent: 5001119 (1991-03-01), Schwartz et al.
patent: 5028631 (1991-07-01), Schwartz et al.
patent: 5206008 (1993-04-01), Loria
patent: 5227907 (1994-01-01), Loria
Phosphates in Food, Ricardo A. Molins Ph.D., CRC Press, p. 190 (1987).
Kalimi, Opoku, Lu, Yanal, Khalid, Regelson & Qureshi, Studies on the Biochemical Action and Mechanism of Dehydroepiandrosterone, 1990, Walter de Gruyter & Co.
Yuan Su and Lardy, Dehydroepiandrosterone-responsive Enzyme Induction in Rat Liver, J. Biochemistry 110:207-213 (1991).
The Faseb Journal, Abstracts, vol. 2, No. 4, Mar. 15, 1988.
Biochem, IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN), 1989, The nomenclature of steroids.
Schauer, Rohrer, Hanson, Lardy & Stratman, "Beta agonist; in Hormones Thermogenesis and Obesity," 1989, Elsevier, N.Y. pp. 485-501.
Lardy, et al., "Dehydroepiandrosterone Induces Enzymes That Permit Thermogenesis and Decrease Metabolic Efficiency," Hormones, Thermogenesis and Obesity (1989), pp. 415-426.
Partridge & Lardy, 1989, Cell Bio. 107;203A, Carbohydrate Chemistry and Metabolism.
Nestler, Barlascini, Clore & Blackard, 1989, Hormones, Thermogenesis & Obesity, Dedrdroepiandrosterones Effects on Insulin Sensitivity Serum Lipid Levels, and Body Composition in Normal Men, pp. 405-414.
Vec, Lopez, The Lancet, Dec. 2, 1989, pp. 1335-1336, Antiglucocorticoid Actions of Dehydroepiandrosterone and Low Concertrations in Alzeimher's Disease.
Lardy, Stratman, 1989, Hormones, Thermogeneis & Obesity, pp. 427-439, Up-Regulation of the Immune Response and Resistance to Virus Infection Dehydroepiandrosterone (DHEA).
Evans, Articles, May 13, 1988, The Steroid and Thyroid Hormone Receptor Superfamily, pp. 889-895.
Flood & Roberts, 1988, Elsevier Science Publishers, pp. 178-181, Dehydroepiandrosterone Sulfate Improves Memory in aging mice.
Chasalow, Blethen, Tobash Myles & Butler, 1987, American Journal of Medical Genetics, Steroid Metabolic Disturbances in Prader-Willi Syndrome, pp. 857-864,
Bailey, Day, Bray, Lipson & Flatt, Dec. 19, 1984, Georg Thieme Venlag Stuttgart Role of Adrenal Glands in the Development of Abnormal Glueose and Insulin Homeostasis in Genetically Obese (ob/ob) Mice, pp. 357-360.
Chasalow, Blethen & Taysi, Oct. & Nov. 1985, pp. 827-843, Steroids, Possible Abnormalities of Steroid Secretion in the Childres with Smith-Lemli-Opitz Syndrome and Their Parents.
Coleman, Leiter & Schwizer, Jun. 17, 1982, pp. 830-833, Rapid Publications, Therapeutic Effects of Dehydroepiandrosterone (DHEA).
Schwartz & Tannen, vol. 2, No. 12, 1981, pp. 1335-1337, Carinogenesis Inhibitation of 7,12-dimethylbenz[a]anthracene-and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone.
Schwatz, Mar. 1979, Cancer Research, pp. 1129-1131, Inhibition of Spontaneous Breast Cancer Formation in Female C3H (A ry/a) Mice by Long Term Treatment with Dehyroepaindrosterone.
Yen, Allen, Pearson, Acton and Greenberg, Lipids, vol. 12, 1977, pp. 409-413, Prevention of obseity in Avy/a Mice By Dehydroepiandrosterone.
Gardner, 1974, Academic Press, Inc., A Sensitive Colorimetric Assay for Mitochondrial alpha Glycerophosphate Dehydrogenase.
Lee & Lardy, Mar. 1965, vol. 240, No. 3, The Journal of Biological Chemistry, Influence of Thyroid Hormones on L-Alpa-Glycerophosphate Dehydrogenases and Other Dehydrogenases in Various Organs of the Rat.
Dodson, Nicholson & Muir, Dec. 5, 1959, pp. 6295-6299, Oxidation of Dehydroisoandrosterone at C-7.
Lee, Takemori Lardy, vol. 234, No. 11, Nov. 1959, The Journal of Biological Chemistry, Enhanced Oxidation of alpha-Glycerophosphate by Mitochondria of Thyroid-fed Rats, pp. 3051-3053.
Gordon, Shantz & Talalay, The Johns Hopkins University School of Medicine Modulation of Growth, Differentiation and Carcinogenesis by Dehydroepiandrosterone, pp. 355-382 (1982).
Effect of Dehydroepiandrosterone Treatment on Liver Metabolism in Rats, Margot P. Cleary, The International Journal of Biochemistry, vol. 22, No. 3, pp. 205-120, 1990.
Anti-Obesity Effect of Two Different Levels of Dehydroepiandrosterone in Lean and Obese Middle-Aged Female Zucker Rats, Margot P. Cleary and Joseph F. Zisk, International Journal of Obesity (1986) vol. 10, pp. 193-204.
Effects of Dietary Dehydroepiandrosterone on Body Weight and Food Consumption in Lethal Yellow (A.sup.y /A.sup.w) and White-Bellied Agouti (A.sup.w /A.sup.w) Mice (Strain 129/Sv), Lisa D. Staber, Nels H. Granholm, Peter J. Wilkin, Proceedings of the South Dakota Academy of Science, vol. 62 (1983), pp. 154-162.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

.DELTA.5-androstenes useful for promoting weight maintenance or does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .DELTA.5-androstenes useful for promoting weight maintenance or , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .DELTA.5-androstenes useful for promoting weight maintenance or will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1310533

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.