.DELTA.16-20-Keto steroid conversion to 17.alpha.-hydroxy-20-ket

Details .DELTA.16-20-Keto steroid conversion to 17.alpha.-hydroxy-20-ket .DELTA.16-20-Keto steroid conversion to 17.alpha.-hydroxy-20-ket

1984-09-14

1986-02-04

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, C07J 7100

Patent

active

045684928

ABSTRACT:
.DELTA.16-20-keto steroids (I) are converted to 17.alpha.-hydroxy-20-keto steroids (III) in 2 steps, hydrosilylation followed by peracid oxidation.

REFERENCES:
patent: 2864834 (1958-12-01), Mendelsohn et al.
patent: 3461144 (1969-08-01), Taub et al.
patent: 3493563 (1970-02-01), Diassi
patent: 4500461 (1985-02-01), Van Rheenen
Journ. Am. Chem. Soc., 78, 5693-5694 (1956), "16-Hydroxylated Steroids . . . " Bernstein et al.
Journ. Am. Chem. Soc., 82, 3399-3404 (1960), "Steroids. CXXXVII..sup.1 Synthesis of a New Class of Potent Cortical Hormones . . . " J. S. Mills et al.
Helv. Chim. Acta, 61, 3068-3071 (1978), "Herstellung von Cortexon-Analogen mit konformativ . . . " P. Wieland.
Journ. of Organometallic Chem., 94, 449-461 (1975), "Reduction of Carbonyl Compounds via Hydrosilylation" Ojima et al.
Tetrahedron Letters No. 49-50, 4319-4322 (1974), "Peracid Oxidation of Trimethylsilyl enol Ethers . . . " G. M. Rubottom et al.

Affiliated with

Also associated with

Rating

.DELTA.16-20-Keto steroid conversion to 17.alpha.-hydroxy-20-ket does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .DELTA.16-20-Keto steroid conversion to 17.alpha.-hydroxy-20-ket, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .DELTA.16-20-Keto steroid conversion to 17.alpha.-hydroxy-20-ket will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2339562