Delivery systems for the controlled administration of LHRH analo

Details Delivery systems for the controlled administration of LHRH analo Delivery systems for the controlled administration of LHRH analo

1987-05-08

1991-07-02

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 78, 514 15, A61F 200, A61K 3174, A61K 3100, A61K 3102

Patent

active

050284304

ABSTRACT:
An implantable polymeric delivery system for the controlled and continuous administration of an LHRH agonist which comprises a silicone elastomer matrix in which is dispersed about 30 to about 42 weight percent of water-soluble particulate phase containing an LHRH analog or a pharmaceutically acceptable salt thereof.

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Lotz et al., J. Pharm. Pharmacol., 31, 649 (1979).
Rhine et al., "A New Approach to Achieve Zero--Order Release Kinetics From Diffusion--Controlled Polymer Matrix Systems" in Controlled Release of Reactive Materials, R. Baker, Ed., Academic Press, 1980.

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