Delivery systems for hydrophobic drugs

Details Delivery systems for hydrophobic drugs Delivery systems for hydrophobic drugs

1997-06-27

2000-08-01

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424452, 514785, 514786, 514937, 514975, A61K 948

Patent

active

060963387

ABSTRACT:
There is provided a carrier for hydrophobic drugs, and pharmaceutical compositions based thereon, which carrier comprises a digestible oil and a pharmaceutically acceptable surfactant component for dispersing the oil in vivo upon administration of the carrier, which comprises a hydrophilic surfactant, said surfactant component being such as not to substantially inhibit the in vivo lipolysis of the digestible oil.

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patent: 5190748 (1993-03-01), Bachynsky et al.
patent: 5342625 (1994-08-01), Hauer et al.
Database WPI, Section CH, Week 8440, Derwent Publications Ltd., London, GB; Class B04, AN 84-246919 & JP-A-59 148 718 (Fujisawa Pharm. KK), Feb. 10, 1983.
Chem. Abstracts, vol. 90, No. 10, Mar. 5, 1979, Columbus, Ohio, US; Abstract No. 76504, Bobbe D. et al.: "Effects of Some Exipients and Adjuvants on the Dissolution Rate of Amidopyrine Present in Soft Capsules" & Bobbe D. et al. "Expo-Congr. Int. Technol. Pharm.," 1977, Assoc. Pharm. Galenique Ind., Chatenay Malabry, Fr.
Chem. Abstracts, vol. 106, No. 16, Apr. 20, 1987, Columbus, OH, US; Abstract No. 125904, Kimura K. et al.: "Menatetrenone Soft Capsules", & Patent Abstracts of Japan, vol. 11, No. 136 (c-419) Apr. 30, 1987 & JP A 61 275214 (Kimura K. et al.) Dec. 5, 1986.

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