Delivery systems

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S054000, C536S001110, C536S018700

Reexamination Certificate

active

10676436

ABSTRACT:
The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.

REFERENCES:
Goodman & Gillman's, The Pharmacological Basis of Therapeutics, 10thEd., 2001, pp. 54-57.
Dekany et al , Peptides, 1996, 331-32.
Dekany et al Peptides, 1996, 331-32.
Neubert Pharmaceutical Research, 1989, 6(9), 743-749.
Chemical Abstract No. 133:242515, Toth et al.,Proc. Eur. Pept. Symp., 25th, pp. 48-49, 1999.
Chemical Abstract No. 129:331004, Dekany et al.,Proc. Eur. Pept. Symp. 24th, pp. 331-332, 1998.
Dubber et al., “Synthesis of Octopus Glycosides: Core Molecules for the Construction of Glycoclusters and Carbohydrate-Centered Dendrimers,”Carbohydrate Research, 310:35-41, 1998.
Gould and Holman, “The Glucose Transporter Family: Structure, Function and Tissue-Specific Expression,”Biochem. J., 295:329-341, 1993.
Green and Hadgraft, “Facilitated Transfer of Cationic Drugs Across a Lipoidal Membrane by Oleic Acid and Lauric Acid,”Int. J. Pharm., 37:251-252, 1987.
Hadgraft et al., “Facilitated Transport of Sodium Salicylate Across an Artificial Lipid Membrane by Azone,”J. Pharm. Pharmacol., 37:725-727, 1985.
Lee et al., “Mucosal Penetration Enhancers for Facilitation of Peptide and Protein Drug Absorption,”Crit. Rev. Thera. Drug Carrier Sys., 8(2):91-192, 1991.
Meyer and Manning, “Hydrophobic Ion Pairing: Altering the Solubility Properties of Biomolecules,”Pharm. Res., 15(2):188-193, 1998.
Mizuma et al., “Factors that Cause the β-Anomeric Preference of Na+/Glucose Cotransporter for Intestinal Transport of Monosaccharide Conjugates,”Biochim. Biophysica. Acta, 1381:340-346, 1998.
Neubert, “Ion Pair Transport Across Membranes,”Pharm. Res., 6(9):743-747, 1989.
Nomoto et al., “Improvement of Intestinal Absorption of Peptide Drugs by Glycosylation: Transport of Tetrapeptide by the Sodium Ion-Dependent D-Glucose Transporter,”J. Pharm. Sci., 87(3):326-332, 1998.
Quintanar-Guerrero et al., “Applications of the Ion-Pair Concept to Hydrophilic Substances with Special Emphasis on Peptides.”Pharm. Res., 14(2):119-127, 1997.
International Search Report for PCT/AU02/00005, mailed Mar. 28, 2002.

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