Delivery system for nucleic acids

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S04400A, C435S455000, C435S458000

Reexamination Certificate

active

07025987

ABSTRACT:
αvβ3Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic αvβ3integrin antagonist.

REFERENCES:
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 5741796 (1998-04-01), Hartman et al.
patent: 6066123 (2000-05-01), Li et al.
patent: 6372250 (2002-04-01), Pardridge
patent: 6458026 (2002-10-01), Hart
patent: 6521211 (2003-02-01), Unger et al.
patent: 2002/0071843 (2002-06-01), Li et al.
patent: 2002/0172711 (2002-11-01), Martin et al.
patent: 2003/0203865 (2003-10-01), Harvie et al.
patent: WO 98/35949 (1998-08-01), None
patent: WO 00/26212 (2000-05-01), None
Storrs et al; “Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging” J. Am. Chem. Soc., 117, pp. 7301-7306 (1995).
Sipkins et al. “Detection of tumor angiogensis in vivo by α, β,-targeted magnetic resonance imaging” Nature Medicine, 4, pp. 623-626 (1998).
Wong et al. “Cationic Lipid Binding to DNA: Characterization of Complex Formation” Biochemistry, 35, pp 5756-5763 (1996).
Cooper et al. “Peptide Mini-Vectors for Gene Delivery” Angew. Chem. Int. Ed., 38, pp 1949-1952 (1999).
Li et al. “Efficient Gene Delivery to Vascular Smooth Muscle Cells Using a Nontoxic, Synthetic Peptide Vector System Targeted to Membrane Integrins: A First Step Toward The Gene Therapy of Chronic Rejection” Transplantation, 70, pp 1616-1624 (2000).
Miller “Cationic Liposomes for Gene Therapy” Angew. Chem. Int. Ed., 37, pp 1769-1785 (1998).
Cooper et al. “Polyamine Analogues of 3β-[N-(N′-N′-Dimethylaminoethane)carbamoyl]-cholesterol (DC-Chol) as Agents for Gene Delivery” Chem. Eur. J., 4, pp 137-151 (1998).
Düffels, et al. “Synthesis of High-Mannose Type Neoglycolipids: Active Targeting of Liposomes to Macrophages in Gene Therapy” Chem. Eur. J., 6, pp 1416-1430 (2000).
Reimer et al. “Formation of Novel Hydrophobic Complexes between Cationic Lipids and Plasmid DNA” Biochemistry, 34, pp 12877-12883 (1995).
Monnard et al. “Entrapment of nucleic acids in liposomes” Biochem. Biophys. Acta, pp 39-50 (1997).
Website of Andrew Miller Research Group at http://www.gtc.ch.ic.ac.uk/miller/catlips. html, accessed on May 13, 2002 “Design, synthesis and testing of non-viral vectors for direct use in gene therapy” and accompanying pdf document entitled “Case History A little bit of lipid helps the medicine go down” hyperlinked thereto.
Xiong et al. “Crystal Structure of the Exrtracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand” Science, 296, pp 151-155 (2002).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Delivery system for nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Delivery system for nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delivery system for nucleic acids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3599930

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.